Special Issue "Monoclonal Antibody Preparation against Natural Product and Its Application"

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A special issue of Antibodies (ISSN 2073-4468).

Deadline for manuscript submissions: closed (31 August 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Yukihiro Shoyama
Professor, Faculty of Pharmaceutical Science, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki 859-3298, Japan
Website: http://www.druglibrary.net/olsen/HEMP/IHA/jiha4211.html
E-Mail: shoyama@niu.ac.jp
Phone: (+81) 956-20-5653
Fax: (+81) 956-20-5622
Interests: monoclonal antibodies; bioactive compounds; marihuana study; isolation and structure elucidation; biotechnology

Special Issue Information

Dear Colleagues,

As the rapid development of the molecular biosciences and their biotechnological application, immunoassay system using monoclonal antibody (MAb) against drugs and bioactive natural products having small molecular weight have become important tools for studies on quantitative and/or qualitative analytical techniques, enzyme assay and receptor binding analysis owing to their specific affinity. However, since direct immunization for small molecular natural product is impossible, conjugate synthesis of natural products with carrier protein is necessary at the first step. MAb can be successful obtained by immunization of mice, hybridoma preparation, selection and cloning of hybridoma and culturing. Although high specific MAb in general will be required, wide-cross reactive MAb is also useful for analysis of total related components. Qualitative and quantitative analysis of bioactive natural product is necessary for the quality control of herbal medicines. Immunostaining like eastern blotting can determine and identify bioactive compounds specifically in crude extract resulting in fingerprinting of herb medicine. Compact MAb, Fc-engineered antibody can be used as a neutralized antibody for the plant breeding. A special issues with focus on “Monoclonal Antibody Preparation against Natural Product and Its Application” will review recent developments and application of MAbs against natural products having small molecule and further accelerate the investigation around MAb against natural product.

Prof. Dr. Yukihiro Shoyama
Guest Editor

Keywords

  • monoclonal antibody
  • natural product having small molecule
  • ELISA
  • quantitative and qualitative analysis
  • finger print analysis
  • eastern blotting
  • immunoaffinity column
  • single chain Fv
  • Fc-engineered antibody

Published Papers (8 papers)

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Displaying article 1-8
p. 452-500
by , ,  and
Antibodies 2013, 2(3), 452-500; doi:10.3390/antib2030452
Received: 23 May 2013; in revised form: 18 July 2013 / Accepted: 2 August 2013 / Published: 16 August 2013
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p. 1-8
by , , ,  and
Antibodies 2013, 2(1), 1-8; doi:10.3390/antib2010001
Received: 9 November 2012; in revised form: 10 December 2012 / Accepted: 14 December 2012 / Published: 21 December 2012
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p. 294-307
by , ,  and
Antibodies 2012, 1(3), 294-307; doi:10.3390/antib1030294
Received: 28 August 2012; in revised form: 30 November 2012 / Accepted: 4 December 2012 / Published: 6 December 2012
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p. 284-293
by , , , , ,  and
Antibodies 2012, 1(3), 284-293; doi:10.3390/antib1030284
Received: 31 August 2012; in revised form: 18 November 2012 / Accepted: 22 November 2012 / Published: 27 November 2012
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p. 273-283
by , , , , , , , , ,  and
Antibodies 2012, 1(3), 273-283; doi:10.3390/antib1030273
Received: 3 September 2012; in revised form: 19 October 2012 / Accepted: 29 October 2012 / Published: 2 November 2012
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p. 259-272
by , , , ,  and
Antibodies 2012, 1(3), 259-272; doi:10.3390/antib1030259
Received: 17 September 2012; in revised form: 28 September 2012 / Accepted: 9 October 2012 / Published: 16 October 2012
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p. 239-258
by , , , , ,  and
Antibodies 2012, 1(2), 239-258; doi:10.3390/antib1020239
Received: 7 August 2012; in revised form: 27 August 2012 / Accepted: 28 August 2012 / Published: 11 September 2012
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p. 215-238
by ,  and
Antibodies 2012, 1(2), 215-238; doi:10.3390/antib1020215
Received: 10 July 2012; in revised form: 16 August 2012 / Accepted: 21 August 2012 / Published: 29 August 2012
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Last update: 20 February 2014

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