Antibodies 2013, 2(3), 452-500; doi:10.3390/antib2030452
Review

Developments and Challenges for mAb-Based Therapeutics

1 Pfizer, Pharmaceutical R&D – BioTherapeutics Pharmaceutical Sciences, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA 2 Alliance Protein Laboratories, 6042 Cornerstone Ct West, Suite A1, San Diego, CA 92121, USA
* Author to whom correspondence should be addressed.
Received: 23 May 2013; in revised form: 18 July 2013 / Accepted: 2 August 2013 / Published: 16 August 2013
PDF Full-text Download PDF Full-Text [867 KB, uploaded 16 August 2013 17:01 CEST]
Abstract: The continuous increase in the number of approved monoclonal antibody (mAb)-based therapy suggests that mAbs, and their derivatives, will continue to be the focus of the biotherapeutics industry for years to come. Although vast improvements in our capability to manufacture, characterize, and stabilize mAbs have been achieved, there are still challenges to be overcome. These include analytical and stabilization approaches associated with the development of high concentration mAb formulations. In addition, several mAb-based modalities are under development, including antibody drug conjugates (ADCs), fusion proteins, and bispecific antibodies (bsAbs), all designed to overcome the limitations encountered with mAb therapy. The current status of their development, with emphasis on manufacturing challenges as well as preliminary clinical results, will be reviewed.
Keywords: monoclonal antibody; fusion-proteins; antibody drug conjugates; fragments; bi-specific

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Goswami, S.; Wang, W.; Arakawa, T.; Ohtake, S. Developments and Challenges for mAb-Based Therapeutics. Antibodies 2013, 2, 452-500.

AMA Style

Goswami S, Wang W, Arakawa T, Ohtake S. Developments and Challenges for mAb-Based Therapeutics. Antibodies. 2013; 2(3):452-500.

Chicago/Turabian Style

Goswami, Sumit; Wang, Wei; Arakawa, Tsutomu; Ohtake, Satoshi. 2013. "Developments and Challenges for mAb-Based Therapeutics." Antibodies 2, no. 3: 452-500.

Antibodies EISSN 2073-4468 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert