Special Issue "Advances in Veterinary Vaccines"

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Special Issue Information
Keywords
Published Papers

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: closed (31 December 2011)

Special Issue Editor

Guest Editor
Dr. Jean-Pierre Scheerlinck
Center for Animal Biotechnology, Faculty of Veterinary Science, The University of Melbourne, Corner Flemington Road and Park Drive, Parkville, Victoria 3010, Australia
Website: http://research.vet.unimelb.edu.au/staff.php?staffID=713
E-Mail: j.scheerlinck@unimelb.edu.au
Phone: +61-3-8344-4441
Fax: +61-3-8344-7374
Interests: regulation of immune responses and lymphocyte recirculation; development of protein and DNA vaccines; animal models for human diseases; infectious diseases

Special Issue Information

Dear Colleagues,

In the last few years there has been a renewed interest in the development of veterinary adjuvants and vaccines, taking advantage of novel technologies in genomics, immunology and infectious diseases. As a result important breakthroughs have been achieved that will shape the way infections of production animals and wildlife will be tackled in the future.

This special issue considers these new advances and their implications in the field of veterinary vaccines. The interplay between human and veterinary vaccine development will also be considered. With increasing threads including the emergence of drug resistance and novel infective agents these “Advances in Veterinary Vaccines” will become critical in the future.

Dr. Jean-Pierre Scheerlinck
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

Keywords

veterinary
vaccines
adjuvants
DNA vaccines
immunity
immune responses
protection
mucosal
systemic

Published Papers (3 papers)

Petra C.F. Oyston and Diane Williamson

Review: Plague: Infections of Companion Animals and Opportunities for Intervention

Animals 2011, 1(2), 242-255; doi:10.3390/ani1020242

Received: 19 May 2011; in revised form: 20 June 2011 / Accepted: 20 June 2011 / Published: 21 June 2011

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Thierry Monney, Karim Debache and Andrew Hemphill

Review: Vaccines against a Major Cause of Abortion in Cattle, Neospora caninum Infection

Animals 2011, 1(3), 306-325; doi:10.3390/ani1030306

Received: 28 July 2011; in revised form: 30 August 2011 / Accepted: 6 September 2011 / Published: 8 September 2011

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Abstract: Neosporosis, caused by the apicomplexan parasite Neospora caninum, represents one of the economically most important causes of abortion in cattle. During pregnancy, the parasite infects the placental tissue and the fetus, which can lead to stillbirth, abortion, or birth of weak calves. Alternatively, calves are born without clinical symptoms, but they can carry over the parasite to the next generation. In addition, N. caninum causes neuromuscular disease in dogs. The economic importance of neosporosis has prompted researchers to invest in the development of measures to prevent infection of cattle by vaccination. A good vaccine must stimulate protective cellular immune responses as well as antibody responses at mucosal sites and, systemically, must activate T-helper cells to produce relevant cytokines, and must elicit specific antibodies that aid in limiting parasite proliferation, e.g., by interference with host cell invasion, activation of complement, and/or opsonization of parasites to have them killed by macrophages. Different types of vaccines have been investigated, either in bovines or in the mouse model. These include live vaccines such as naturally less virulent isolates of N. caninum, attenuated strains generated by irradiation or chemical means, or genetically modified transgenic strains. Live vaccines were shown to be very effective; however, there are serious disadvantages in terms of safety, costs of production, and stability of the final product. Subunit vaccines have been intensively studied, as they would have clear advantages such as reduced costs in production, processing and storage, increased stability and shelf life. The parasite antigens involved in adhesion and invasion of host cells, such as surface constituents, microneme-, rhoptry- and dense granule-components represent interesting targets. Subunit vaccines have been applied as bacterially expressed recombinant antigens or as DNA vaccines. Besides monovalent vaccines also polyvalent combinations of different antigens have been used, providing increased protection. Vaccines have been combined with immunostimulating carriers and, more recently, chimeric vaccines, incorporating immuno-relevant domains of several antigens into a single protein, have been developed.

Samantha Dozier, Jeffrey Brown and Alistair Currie

Article: Bridging the Gap Between Validation and Implementation of Non-Animal Veterinary Vaccine Potency Testing Methods

Animals 2011, 1(4), 414-432; doi:10.3390/ani1040414

Received: 29 October 2011; in revised form: 19 November 2011 / Accepted: 22 November 2011 / Published: 29 November 2011

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Last update: 18 August 2011

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