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Biomimetic Strategies for Bone Repair and Regeneration
Institute of Composite and Biomedical Materials, National Research Council of Italy, P.le Tecchio 80, Naples 80125, Italy
* Author to whom correspondence should be addressed.
Received: 29 May 2012; in revised form: 30 August 2012 / Accepted: 31 August 2012 / Published: 20 September 2012
Abstract: The osseointegration rate of implants is related to their composition and surface roughness. Implant roughness favors both bone anchoring and biomechanical stability. Osteoconductive calcium phosphate (Ca-P) coatings promote bone healing and apposition, leading to the rapid biological fixation of implants. It has been clearly shown in many publications that Ca-P coating accelerates bone formation around the implant. This review discusses two main routes for the manufacturing of polymer-based osteoconductive scaffolds for tissue engineering, namely the incorporation of bioceramic particles in the scaffold and the coating of a scaffold with a thin layer of apatite through a biomimetic process.
Keywords: biomimetic coating; bone substitute; hydroxyapatite; scaffold
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Raucci, M.G.; Guarino, V.; Ambrosio, L. Biomimetic Strategies for Bone Repair and Regeneration. J. Funct. Biomater. 2012, 3, 688-705.
Raucci MG, Guarino V, Ambrosio L. Biomimetic Strategies for Bone Repair and Regeneration. Journal of Functional Biomaterials. 2012; 3(3):688-705.
Raucci, Maria G.; Guarino, Vincenzo; Ambrosio, Luigi. 2012. "Biomimetic Strategies for Bone Repair and Regeneration." J. Funct. Biomater. 3, no. 3: 688-705.