J. Funct. Biomater. 2012, 3(3), 615-641; doi:10.3390/jfb3030615
Review

Biocompatibility of Chitosan Carriers with Application in Drug Delivery

1,†
, 1,†
, 2
 and 1,*
Received: 26 June 2012; in revised form: 3 August 2012 / Accepted: 21 August 2012 / Published: 17 September 2012
(This article belongs to the Special Issue Biocompatibility of Biomaterials)
View Full-Text   |   Download PDF [570 KB, updated 18 September 2012; original version uploaded 17 September 2012]
Abstract: Chitosan is one of the most used polysaccharides in the design of drug delivery strategies for administration of either biomacromolecules or low molecular weight drugs. For these purposes, it is frequently used as matrix forming material in both nano and micron-sized particles. In addition to its interesting physicochemical and biopharmaceutical properties, which include high mucoadhesion and a great capacity to produce drug delivery systems, ensuring the biocompatibility of the drug delivery vehicles is a highly relevant issue. Nevertheless, this subject is not addressed as frequently as desired and even though the application of chitosan carriers has been widely explored, the demonstration of systems biocompatibility is still in its infancy. In this review, addressing the biocompatibility of chitosan carriers with application in drug delivery is discussed and the methods used in vitro and in vivo, exploring the effect of different variables, are described. We further provide a discussion on the pros and cons of used methodologies, as well as on the difficulties arising from the absence of standardization of procedures.
Keywords: biocompatibility; chitosan; cytotoxicity; genotoxicity; microparticles; nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Rodrigues, S.; Dionísio, M.; López, C.R.; Grenha, A. Biocompatibility of Chitosan Carriers with Application in Drug Delivery. J. Funct. Biomater. 2012, 3, 615-641.

AMA Style

Rodrigues S, Dionísio M, López CR, Grenha A. Biocompatibility of Chitosan Carriers with Application in Drug Delivery. Journal of Functional Biomaterials. 2012; 3(3):615-641.

Chicago/Turabian Style

Rodrigues, Susana; Dionísio, Marita; López, Carmen Remuñán; Grenha, Ana. 2012. "Biocompatibility of Chitosan Carriers with Application in Drug Delivery." J. Funct. Biomater. 3, no. 3: 615-641.



J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert