Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
J. Funct. Biomater. 2012, 3(1), 131-142; doi:10.3390/jfb3010131
Article

Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples

1
, 1
, 1
, 1
, 2
, 3
, 1
 and 1,*
Received: 12 January 2012; in revised form: 11 February 2012 / Accepted: 11 February 2012 / Published: 20 February 2012
(This article belongs to the Special Issue Molecularly Imprinted Polymers in Biomedical Applications)
View Full-Text   |   Download PDF [781 KB, updated 21 February 2012; original version uploaded 20 February 2012]
Abstract: A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine were selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 µmol•g−1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples.
Keywords: molecularly imprinted polymer; irinotecan; human serum; LC-PDA molecularly imprinted polymer; irinotecan; human serum; LC-PDA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Roy, B.; Vo Duy, S.; Puy, J.-Y.; Martin, C.; Guitton, J.; Dumontet, C.; Périgaud, C.; Lefebvre-Tournier, I. Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples. J. Funct. Biomater. 2012, 3, 131-142.

AMA Style

Roy B, Vo Duy S, Puy J-Y, Martin C, Guitton J, Dumontet C, Périgaud C, Lefebvre-Tournier I. Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples. Journal of Functional Biomaterials. 2012; 3(1):131-142.

Chicago/Turabian Style

Roy, Béatrice; Vo Duy, Sung; Puy, Jean-Yves; Martin, Charlotte; Guitton, Jérome; Dumontet, Charles; Périgaud, Christian; Lefebvre-Tournier, Isabelle. 2012. "Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples." J. Funct. Biomater. 3, no. 1: 131-142.



J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert