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A Path to Soluble Molecularly Imprinted Polymers
J. Funct. Biomater. 2012, 3(1), 131-142; doi:10.3390/jfb3010131

Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples

1 Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France 2 Laboratoire de Ciblage Thérapeutique en Cancérologie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite F-69495, France 3 Laboratoire de Cytologie Analytique, Inserm U590, Université Lyon 1, Lyon F-69008, France
* Author to whom correspondence should be addressed.
Received: 12 January 2012 / Revised: 11 February 2012 / Accepted: 11 February 2012 / Published: 20 February 2012
(This article belongs to the Special Issue Molecularly Imprinted Polymers in Biomedical Applications)
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A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine were selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 µmol•g−1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples.
Keywords: molecularly imprinted polymer; irinotecan; human serum; LC-PDA molecularly imprinted polymer; irinotecan; human serum; LC-PDA
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Roy, B.; Vo Duy, S.; Puy, J.-Y.; Martin, C.; Guitton, J.; Dumontet, C.; Périgaud, C.; Lefebvre-Tournier, I. Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples. J. Funct. Biomater. 2012, 3, 131-142.

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