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Soft Polymers for Building up Small and Smallest Blood Supplying Systems by Stereolithography
Fraunhofer Institute of Applied Polymer Research (IAP), Geiselbergstr 69, Potsdam 14476, Germany
Rheinisch-Westfälische Technische Hochschule Aachen, RWTH Aachen, Steinbachstraße 15, Aachen 52074, Germany
Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstraße 12, Stuttgart 70569, Germany
* Author to whom correspondence should be addressed.
Received: 16 February 2012; in revised form: 16 March 2012 / Accepted: 20 March 2012 / Published: 29 March 2012
Abstract: Synthesis of a homologous series of photo-polymerizable α,w-polytetrahydrofuranether-diacrylate (PTHF-DA) resins is described with characterization by NMR, GPC, DSC, soaking and rheometrical measurements. The curing speeds of the resins are determined under UV light exposure. Young’s modulus and tensile strength of fully cured resins show flexible to soft material attributes dependent on the molar mass of the used linear PTHF-diacrylates. Structuring the materials by stereo lithography (SL) and multiphoton polymerization (MPP) leads to tubes and bifurcated tube systems with a diameter smaller than 2 mm aimed at small to smallest supplying systems with capillary dimensions. WST-1 biocompatibility tests ofm polymer extracts show nontoxic characteristics of the adapted polymers after a washing process. Some polymers show shape memory effect (SME).
Keywords: functional biopolymers; biocompatibility; biomedical devices; tissue devices; rapid prototyping
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Meyer, W.; Engelhardt, S.; Novosel, E.; Elling, B.; Wegener, M.; Krüger, H. Soft Polymers for Building up Small and Smallest Blood Supplying Systems by Stereolithography. J. Funct. Biomater. 2012, 3, 257-268.
Meyer W, Engelhardt S, Novosel E, Elling B, Wegener M, Krüger H. Soft Polymers for Building up Small and Smallest Blood Supplying Systems by Stereolithography. Journal of Functional Biomaterials. 2012; 3(2):257-268.
Meyer, Wolfdietrich; Engelhardt, Sascha; Novosel, Esther; Elling, Burkhard; Wegener, Michael; Krüger, Hartmut. 2012. "Soft Polymers for Building up Small and Smallest Blood Supplying Systems by Stereolithography." J. Funct. Biomater. 3, no. 2: 257-268.