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Vaccines 2014, 2(2), 354-379; doi:10.3390/vaccines2020354
Review

HIV DNA Vaccine: Stepwise Improvements Make a Difference

1,* , 2
, 2
, 1
 and 2
1 Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA 2 Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA
* Author to whom correspondence should be addressed.
Received: 21 February 2014 / Revised: 11 April 2014 / Accepted: 18 April 2014 / Published: 14 May 2014
(This article belongs to the Special Issue DNA Vaccines)
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Abstract

Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic.
Keywords: macaque; cytokine; plasmid; electroporation; immunogenicity; vaccination; DNA delivery; DNA expression macaque; cytokine; plasmid; electroporation; immunogenicity; vaccination; DNA delivery; DNA expression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Felber, B.K.; Valentin, A.; Rosati, M.; Bergamaschi, C.; Pavlakis, G.N. HIV DNA Vaccine: Stepwise Improvements Make a Difference. Vaccines 2014, 2, 354-379.

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