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Vaccines 2014, 2(2), 354-379; doi:10.3390/vaccines2020354
Review

HIV DNA Vaccine: Stepwise Improvements Make a Difference

1,* , 2
,
2
,
1
 and
2
1 Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA 2 Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA
* Author to whom correspondence should be addressed.
Received: 21 February 2014 / Revised: 11 April 2014 / Accepted: 18 April 2014 / Published: 14 May 2014
(This article belongs to the Special Issue DNA Vaccines)
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Abstract

Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic.
Keywords: macaque; cytokine; plasmid; electroporation; immunogenicity; vaccination; DNA delivery; DNA expression macaque; cytokine; plasmid; electroporation; immunogenicity; vaccination; DNA delivery; DNA expression
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Felber, B.K.; Valentin, A.; Rosati, M.; Bergamaschi, C.; Pavlakis, G.N. HIV DNA Vaccine: Stepwise Improvements Make a Difference. Vaccines 2014, 2, 354-379.

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