Special Issue "DNA Vaccines"
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (15 May 2013)
Prof. Dr. Margaret A. Liu
1 ProTherImmune, 3656 Happy Valley Road Lafayette, CA 94549, USA 2 Karolinska Institute, Stockholm SE-17177, Sweden
Phone: +1 925 299 2959
Fax: +1 925 299 2959
Interests: vaccine technologies; DNA vaccines; cellular immune responses; HIV Vvccines; global health
Prof. Dr. Britta Wahren
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet Center for HIV research, Nobel´s Road 16, 171 77 Stockholm, Sweden
Interests: infectious diseases; virology; tumor biology; HIV vaccines; genetic vaccines
During the last few years, there has been immense progress in the field of gene-based vaccines. This has been a result of new and better vectors, improved expression constructs, different types of delivery methods and devices, and it may be said, selection of optimal diseases/antigens and vaccinees. Several products have been licensed for veterinary applications, including infectious diseases and cancer. New human clinical trials have been initiated, and a number of phase 1-2 trials concluded. The present issue on “Research progress for gene-based vaccines” will bring together primary data and up-to-date summaries of break-throughs in using DNA plasmids for vaccines and immunotherapies. It will also show the possibilities of gene therapy, for which there is one licensed veterinary product and a different human one. To exemplify the progress, the situation for several severe infectious diseases and tumors will be depicted together with future views for further translation into the clinic.
It is 20 years since the first data on DNA vaccines were publicly presented at Cold Spring Harbor, 1992. Clinical trials of DNA vaccines are in progress for many diseases including HIV, HCV, malaria, influenza, tuberculosis and tumors (colo-rectal, prostate, melanoma). These include plasmid constructs used as a prime for boosting with other types of vaccines.
Prof. Dr. Margaret A. Liu
Prof. Dr. Britta Wahren
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- DNA vaccine
- RNA vaccine
- infectious diseases
- autoimmune diseases
- immune mechanisms
- T cells
- innate immunity
- delivery technology
Vaccines 2013, 1(3), 225-249; doi:10.3390/vaccines1030225
Received: 14 May 2013; in revised form: 12 June 2013 / Accepted: 18 June 2013 / Published: 25 June 2013| Download PDF Full-text (653 KB) | Download XML Full-text
Article: Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation
Vaccines 2013, 1(3), 262-277; doi:10.3390/vaccines1030262
Received: 31 May 2013; in revised form: 8 July 2013 / Accepted: 10 July 2013 / Published: 18 July 2013| Download PDF Full-text (512 KB) | Download XML Full-text
Vaccines 2013, 1(3), 278-292; doi:10.3390/vaccines1030278
Received: 13 June 2013; in revised form: 6 July 2013 / Accepted: 9 July 2013 / Published: 18 July 2013| Download PDF Full-text (685 KB) | Download XML Full-text
Article: Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques
Vaccines 2013, 1(3), 305-327; doi:10.3390/vaccines1030305
Received: 16 May 2013; in revised form: 5 July 2013 / Accepted: 10 July 2013 / Published: 19 July 2013| Download PDF Full-text (724 KB) | Download XML Full-text | Supplementary Files
Vaccines 2013, 1(3), 367-383; doi:10.3390/vaccines1030367
Received: 26 June 2013; in revised form: 12 August 2013 / Accepted: 14 August 2013 / Published: 22 August 2013| Download PDF Full-text (1824 KB) | Download XML Full-text
Article: Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation
Vaccines 2013, 1(3), 384-397; doi:10.3390/vaccines1030384
Received: 16 July 2013; in revised form: 13 August 2013 / Accepted: 21 August 2013 / Published: 28 August 2013| Download PDF Full-text (837 KB) | Download XML Full-text
Case Report: Clinical Development of a Cytomegalovirus DNA Vaccine: From Product Concept to Pivotal Phase 3 Trial
Vaccines 2013, 1(4), 398-414; doi:10.3390/vaccines1040398
Received: 10 July 2013; in revised form: 23 August 2013 / Accepted: 28 August 2013 / Published: 25 September 2013| Download PDF Full-text (550 KB) | Download XML Full-text
Article: DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant
Vaccines 2013, 1(4), 415-443; doi:10.3390/vaccines1040415
Received: 18 July 2013; in revised form: 27 August 2013 / Accepted: 30 August 2013 / Published: 25 September 2013| Download PDF Full-text (940 KB) | Download XML Full-text
Article: Evaluation of Different DNA Vaccines against Porcine Reproductive and Respiratory Syndrome (PRRS) in Pigs
Vaccines 2013, 1(4), 463-480; doi:10.3390/vaccines1040463
Received: 30 July 2013; in revised form: 10 September 2013 / Accepted: 9 October 2013 / Published: 18 October 2013| Download PDF Full-text (459 KB) | Download XML Full-text
Last update: 16 January 2013