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Micromachines 2014, 5(3), 607-621; doi:10.3390/mi5030607
Article

An Optofluidic Lens Array Microchip for High Resolution Stereo Microscopy

1
,
2
,
3
 and
1,2,3,*
1 Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA 2 Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA 3 Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
* Author to whom correspondence should be addressed.
Received: 9 June 2014 / Revised: 10 August 2014 / Accepted: 20 August 2014 / Published: 28 August 2014
(This article belongs to the Special Issue Microlenses)
View Full-Text   |   Download PDF [11155 KB, 10 September 2014; original version 28 August 2014]   |  

Abstract

We report the development of an add-on, chip-based, optical module—termed the Microfluidic-based Oil-immersion Lenses (μOIL) chip—which transforms any stereo microscope into a high-resolution, large field of view imaging platform. The μOIL chip consists of an array of ball mini-lenses that are assembled onto a microfluidic silicon chip. The mini-lenses are made out of high refractive index material (sapphire) and they are half immersed in oil. Those two key features enable submicron resolution and a maximum numerical aperture of ~1.2. The μOIL chip is reusable and easy to operate as it can be placed directly on top of any biological sample. It improves the resolution of a stereo microscope by an order of magnitude without compromising the field of view; therefore, we believe it could become a versatile tool for use in various research studies and clinical applications.
Keywords: ball lens; microscope; oil immersion lens; microlens; stereo microscope; high resolution imaging; add-on module; optofluidics; microfabrication ball lens; microscope; oil immersion lens; microlens; stereo microscope; high resolution imaging; add-on module; optofluidics; microfabrication
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gulari, M.N.; Tripathi, A.; Ghannad-Rezaie, M.; Chronis, N. An Optofluidic Lens Array Microchip for High Resolution Stereo Microscopy. Micromachines 2014, 5, 607-621.

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