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Micromachines 2014, 5(3), 607-621; doi:10.3390/mi5030607
Article

An Optofluidic Lens Array Microchip for High Resolution Stereo Microscopy

1
, 2
, 3
 and 1,2,3,*
Received: 9 June 2014; in revised form: 10 August 2014 / Accepted: 20 August 2014 / Published: 28 August 2014
(This article belongs to the Special Issue Microlenses)
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Abstract: We report the development of an add-on, chip-based, optical module—termed the Microfluidic-based Oil-immersion Lenses (μOIL) chip—which transforms any stereo microscope into a high-resolution, large field of view imaging platform. The μOIL chip consists of an array of ball mini-lenses that are assembled onto a microfluidic silicon chip. The mini-lenses are made out of high refractive index material (sapphire) and they are half immersed in oil. Those two key features enable submicron resolution and a maximum numerical aperture of ~1.2. The μOIL chip is reusable and easy to operate as it can be placed directly on top of any biological sample. It improves the resolution of a stereo microscope by an order of magnitude without compromising the field of view; therefore, we believe it could become a versatile tool for use in various research studies and clinical applications.
Keywords: ball lens; microscope; oil immersion lens; microlens; stereo microscope; high resolution imaging; add-on module; optofluidics; microfabrication ball lens; microscope; oil immersion lens; microlens; stereo microscope; high resolution imaging; add-on module; optofluidics; microfabrication
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gulari, M.N.; Tripathi, A.; Ghannad-Rezaie, M.; Chronis, N. An Optofluidic Lens Array Microchip for High Resolution Stereo Microscopy. Micromachines 2014, 5, 607-621.

AMA Style

Gulari MN, Tripathi A, Ghannad-Rezaie M, Chronis N. An Optofluidic Lens Array Microchip for High Resolution Stereo Microscopy. Micromachines. 2014; 5(3):607-621.

Chicago/Turabian Style

Gulari, Mayurachat N.; Tripathi, Anurag; Ghannad-Rezaie, Mostafa; Chronis, Nikos. 2014. "An Optofluidic Lens Array Microchip for High Resolution Stereo Microscopy." Micromachines 5, no. 3: 607-621.


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