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Toxins 2012, 4(2), 83-97; doi:10.3390/toxins4020083

Cytoskeleton as an Emerging Target of Anthrax Toxins

1 Unité Interactions Hôte-Agents pathogènes, Institut de Recherche Biomédicale des Armées, Centre de Recherche du Service de Santé des Armées, BP 87, 24 avenue des Maquis du Grésivaudan 38702 La Tronche Cedex, France 2 Ecole du Val-de-Grâce, 1 place Alphonse Lavéran, 75005 Paris, France
* Author to whom correspondence should be addressed.
Received: 10 January 2012 / Revised: 21 January 2012 / Accepted: 26 January 2012 / Published: 6 February 2012
(This article belongs to the Special Issue Anthrax Toxin)
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Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity.
Keywords: : anthrax toxins; cytoskeleton; actin; phagocytosis; vascular integrity : anthrax toxins; cytoskeleton; actin; phagocytosis; vascular integrity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Trescos, Y.; Tournier, J.-N. Cytoskeleton as an Emerging Target of Anthrax Toxins. Toxins 2012, 4, 83-97.

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