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Nutrients 2013, 5(9), 3506-3530; doi:10.3390/nu5093506
Review

Immunometabolism in Obese Asthmatics: Are We There Yet?

1
, 1,2,*  and 1
Received: 1 July 2013; in revised form: 30 August 2013 / Accepted: 30 August 2013 / Published: 10 September 2013
(This article belongs to the Special Issue Nutrition and Respiratory Disease)
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Abstract: Obesity is now recognised as a worldwide epidemic. The recent International Association for the Study of Obesity/International Obesity Taskforce (IASO/IOTF) analysis estimates that approximately 1.0 billion adults are currently overweight and a further 475 million are obese. Obesity has huge psychosocial impact with obese children and adolescents facing discrimination and stigmatization in many areas of their lives leading to body dissatisfaction, low self-esteem and depression. Indeed, obesity is recognised as an important risk factor for the development of several chronic diseases such as hypertension, cancer, asthma and metabolic syndrome. Chronic low grade systemic inflammation is considered as a hallmark of obesity and may possibly explain the link between obesity and chronic disease, in particular the increased incidence, prevalence and severity of asthma in obese individuals. There is now strong evidence for infiltration of immune and inflammatory cells into adipose tissue that drives systemic inflammation and subsequent end organ damage. In addition to adipocytes, the key adipose tissue resident immune cells are macrophages and mast cells. Immunometabolism, as an emerging field of investigation, explores the pivotal role of these immune cells in translating immunological changes to metabolic effects in obesity. Abundance of free fatty acids, along with other inflammatory cytokines shift the balance of metabolic homeostasis to pro-inflammatory status by influencing the development of inflammatory cell lineage, which, further exhibits distinct functional phenotypes. There is emerging evidence for macrophage activation and functional polarization of an anti-inflammatory M2 phenotype towards a pro-inflammatory M1 phenotype of macrophages in obese adipose tissue. Similarly, studies in both obese humans and murine models reveal the pathognomic presence of an increased number of mast cells in visceral adipose tissue. These suggest a possible contribution of mast cells to the unique metabolome of obese asthma. This review examines proposed multilevel interactions between metabolic and immune systems in obese asthmatics that underlie the negative effects of obesity and may offer significant therapeutic promise.
Keywords: obesity; immunometabolism; macrophages; mast cells; asthma obesity; immunometabolism; macrophages; mast cells; asthma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Periyalil, H.A.; Gibson, P.G.; Wood, L.G. Immunometabolism in Obese Asthmatics: Are We There Yet? Nutrients 2013, 5, 3506-3530.

AMA Style

Periyalil HA, Gibson PG, Wood LG. Immunometabolism in Obese Asthmatics: Are We There Yet? Nutrients. 2013; 5(9):3506-3530.

Chicago/Turabian Style

Periyalil, Hashim A.; Gibson, Peter G.; Wood, Lisa G. 2013. "Immunometabolism in Obese Asthmatics: Are We There Yet?" Nutrients 5, no. 9: 3506-3530.



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