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Increasing Vitamin C Content in Plant Foods to Improve Their Nutritional Value—Successes and Challenges
Nutrients 2013, 5(9), 3496-3505; doi:10.3390/nu5093496

The Effects of High Concentrations of Vitamin C on Cancer Cells

Department of Applied Chemistry, Dongduk Women's University, 23-1 Wolgok-dong, Sungbuk-ku, Seoul 136-714, Korea
Received: 8 July 2013 / Revised: 22 August 2013 / Accepted: 23 August 2013 / Published: 9 September 2013
(This article belongs to the Special Issue Vitamin C and Human Health)
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The effect of high doses of vitamin C for the treatment of cancer has been controversial. Our previous studies, and studies by others, have reported that vitamin C at concentrations of 0.25–1.0 mM induced a dose- and time-dependent inhibition of proliferation in acute myeloid leukemia (AML) cell lines and in leukemic cells from peripheral blood specimens obtained from patients with AML. Treatment of cells with high doses of vitamin C resulted in an immediate increase in intracellular total glutathione content and glutathione-S transferase activity that was accompanied by the uptake of cysteine. These results suggest a new role for high concentrations of vitamin C in modulation of intracellular sulfur containing compounds, such as glutathione and cysteine. This review, discussing biochemical pharmacologic studies, including pharmacogenomic and pharmacoproteomic studies, presents the different pharmacological effects of vitamin C currently under investigation.
Keywords: high concentrations of vitamin C; pharmacogenomics; pharmacoproteomics high concentrations of vitamin C; pharmacogenomics; pharmacoproteomics
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Park, S. The Effects of High Concentrations of Vitamin C on Cancer Cells. Nutrients 2013, 5, 3496-3505.

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