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The Effects of High Concentrations of Vitamin C on Cancer Cells
Department of Applied Chemistry, Dongduk Women's University, 23-1 Wolgok-dong, Sungbuk-ku, Seoul 136-714, Korea
Received: 8 July 2013; in revised form: 22 August 2013 / Accepted: 23 August 2013 / Published: 9 September 2013
Abstract: The effect of high doses of vitamin C for the treatment of cancer has been controversial. Our previous studies, and studies by others, have reported that vitamin C at concentrations of 0.25–1.0 mM induced a dose- and time-dependent inhibition of proliferation in acute myeloid leukemia (AML) cell lines and in leukemic cells from peripheral blood specimens obtained from patients with AML. Treatment of cells with high doses of vitamin C resulted in an immediate increase in intracellular total glutathione content and glutathione-S transferase activity that was accompanied by the uptake of cysteine. These results suggest a new role for high concentrations of vitamin C in modulation of intracellular sulfur containing compounds, such as glutathione and cysteine. This review, discussing biochemical pharmacologic studies, including pharmacogenomic and pharmacoproteomic studies, presents the different pharmacological effects of vitamin C currently under investigation.
Keywords: high concentrations of vitamin C; pharmacogenomics; pharmacoproteomics
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MDPI and ACS Style
Park, S. The Effects of High Concentrations of Vitamin C on Cancer Cells. Nutrients 2013, 5, 3496-3505.
Park S. The Effects of High Concentrations of Vitamin C on Cancer Cells. Nutrients. 2013; 5(9):3496-3505.
Park, Seyeon. 2013. "The Effects of High Concentrations of Vitamin C on Cancer Cells." Nutrients 5, no. 9: 3496-3505.