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Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models
Department of Human Genetics, McGill University, 1205 Avenue Docteur Penfield, N5/13,Montreal, Quebec, Canada H3A 1B1
Department of Pediatrics, McGill University, Montreal, Quebec, Canada H3H 1P3
McGill University Health Centre, 4060 Ste. Catherine West, PT 420, Montreal, Quebec, Canada H3Z 2Z3
* Author to whom correspondence should be addressed.
Received: 5 July 2013; in revised form: 10 August 2013 / Accepted: 23 August 2013 / Published: 10 September 2013
Abstract: Vitamin B12 (cobalamin, Cbl) is required for cellular metabolism. It is an essential coenzyme in mammals for two reactions: the conversion of homocysteine to methionine by the enzyme methionine synthase and the conversion of methylmalonyl-CoA to succinyl-CoA by the enzyme methylmalonyl-CoA mutase. Symptoms of Cbl deficiency are hematological, neurological and cognitive, including megaloblastic anaemia, tingling and numbness of the extremities, gait abnormalities, visual disturbances, memory loss and dementia. During pregnancy Cbl is essential, presumably because of its role in DNA synthesis and methionine synthesis; however, there are conflicting studies regarding an association between early pregnancy loss and Cbl deficiency. We here review the literature about the requirement for Cbl during pregnancy, and summarized what is known of the expression pattern and function of genes required for Cbl metabolism in embryonic mouse models.
Keywords: cobalamin; mouse models; development; metabolism; vitamin B12
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Moreno-Garcia, M.A.; Rosenblatt, D.S.; Jerome-Majewska, L.A. Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models. Nutrients 2013, 5, 3531-3550.
Moreno-Garcia MA, Rosenblatt DS, Jerome-Majewska LA. Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models. Nutrients. 2013; 5(9):3531-3550.
Moreno-Garcia, Maira A.; Rosenblatt, David S.; Jerome-Majewska, Loydie A. 2013. "Vitamin B12 Metabolism during Pregnancy and in Embryonic Mouse Models." Nutrients 5, no. 9: 3531-3550.