Nutrients 2013, 5(7), 2611-2628; doi:10.3390/nu5072611

Influence of microRNA on the Maintenance of Human Iron Metabolism

email and * email
Received: 2 May 2013; in revised form: 19 June 2013 / Accepted: 24 June 2013 / Published: 10 July 2013
(This article belongs to the Special Issue Dietary Iron and Human Health)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Iron is an essential nutrient critical for many cellular functions including DNA synthesis, ATP generation, and cellular proliferation. Though essential, excessive iron may contribute to the generation of free radicals capable of damaging cellular lipids, proteins, and nucleic acids. As such, the maintenance and control of cellular iron homeostasis is critical to prevent either iron deficiency or iron toxicity conditions. The maintenance of cellular iron homeostasis is largely coordinated by a family of cytosolic RNA binding proteins known as Iron Regulatory Proteins (IRP) that function to post-transcriptionally control the translation and/or stability of mRNA encoding proteins required for iron uptake, storage, transport, and utilization. More recently, a class of small non-coding RNA known as microRNA (miRNA) has also been implicated in the control of iron metabolism. To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin). Given the diversity of miRNA and number of potential mRNA targets, characterizing factors that contribute to alterations in miRNA expression, biogenesis, and processing will enhance our understanding of mechanisms by which cells respond to changes in iron demand and/or iron availability to control cellular iron homeostasis.
Keywords: diet; cell metabolism; iron homeostasis; microRNA regulation
PDF Full-text Download PDF Full-Text [495 KB, uploaded 10 July 2013 13:40 CEST]

Export to BibTeX |

MDPI and ACS Style

Davis, M.; Clarke, S. Influence of microRNA on the Maintenance of Human Iron Metabolism. Nutrients 2013, 5, 2611-2628.

AMA Style

Davis M, Clarke S. Influence of microRNA on the Maintenance of Human Iron Metabolism. Nutrients. 2013; 5(7):2611-2628.

Chicago/Turabian Style

Davis, McKale; Clarke, Stephen. 2013. "Influence of microRNA on the Maintenance of Human Iron Metabolism." Nutrients 5, no. 7: 2611-2628.

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert