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Nutrients 2013, 5(7), 2333-2351; doi:10.3390/nu5072333
Review

Intestinal Iron Homeostasis and Colon Tumorigenesis

1
 and 1,2,*
Received: 3 May 2013; in revised form: 29 May 2013 / Accepted: 7 June 2013 / Published: 28 June 2013
(This article belongs to the Special Issue Dietary Iron and Human Health)
View Full-Text   |   Download PDF [551 KB, uploaded 28 June 2013]
Abstract: Colorectal cancer (CRC) is the third most common cause of cancer-related deaths in industrialized countries. Understanding the mechanisms of growth and progression of CRC is essential to improve treatment. Iron is an essential nutrient for cell growth. Iron overload caused by hereditary mutations or excess dietary iron uptake has been identified as a risk factor for CRC. Intestinal iron is tightly controlled by iron transporters that are responsible for iron uptake, distribution, and export. Dysregulation of intestinal iron transporters are observed in CRC and lead to iron accumulation in tumors. Intratumoral iron results in oxidative stress, lipid peroxidation, protein modification and DNA damage with consequent promotion of oncogene activation. In addition, excess iron in intestinal tumors may lead to increase in tumor-elicited inflammation and tumor growth. Limiting intratumoral iron through specifically chelating excess intestinal iron or modulating activities of iron transporter may be an attractive therapeutic target for CRC.
Keywords: iron; colorectal cancer; divalent metal transporter-1 (DMT-1); hepcidin; HIF; ferroportin (FPN) iron; colorectal cancer; divalent metal transporter-1 (DMT-1); hepcidin; HIF; ferroportin (FPN)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xue, X.; Shah, Y.M. Intestinal Iron Homeostasis and Colon Tumorigenesis. Nutrients 2013, 5, 2333-2351.

AMA Style

Xue X, Shah YM. Intestinal Iron Homeostasis and Colon Tumorigenesis. Nutrients. 2013; 5(7):2333-2351.

Chicago/Turabian Style

Xue, Xiang; Shah, Yatrik M. 2013. "Intestinal Iron Homeostasis and Colon Tumorigenesis." Nutrients 5, no. 7: 2333-2351.



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