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Nutrients 2013, 5(8), 2836-2859; doi:10.3390/nu5082836

Iron Deprivation in Cancer––Potential Therapeutic Implications

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Received: 4 June 2013 / Revised: 12 July 2013 / Accepted: 16 July 2013 / Published: 24 July 2013
(This article belongs to the Special Issue Dietary Iron and Human Health)
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Abstract: Iron is essential for normal cellular function. It participates in a wide variety of cellular processes, including cellular respiration, DNA synthesis, and macromolecule biosynthesis. Iron is required for cell growth and proliferation, and changes in intracellular iron availability can have significant effects on cell cycle regulation, cellular metabolism, and cell division. Perhaps not surprisingly then, neoplastic cells have been found to have higher iron requirements than normal, non-malignant cells. Iron depletion through chelation has been explored as a possible therapeutic intervention in a variety of cancers. Here, we will review iron homeostasis in non-malignant and malignant cells, the widespread effects of iron depletion on the cell, the various iron chelators that have been explored in the treatment of cancer, and the tumor types that have been most commonly studied in the context of iron chelation.
Keywords: iron; chelation; cancer; leukemia; neuroblastoma; ribonucleotide reductase iron; chelation; cancer; leukemia; neuroblastoma; ribonucleotide reductase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Heath, J.L.; Weiss, J.M.; Lavau, C.P.; Wechsler, D.S. Iron Deprivation in Cancer––Potential Therapeutic Implications. Nutrients 2013, 5, 2836-2859.

AMA Style

Heath JL, Weiss JM, Lavau CP, Wechsler DS. Iron Deprivation in Cancer––Potential Therapeutic Implications. Nutrients. 2013; 5(8):2836-2859.

Chicago/Turabian Style

Heath, Jessica L.; Weiss, Joshua M.; Lavau, Catherine P.; Wechsler, Daniel S. 2013. "Iron Deprivation in Cancer––Potential Therapeutic Implications." Nutrients 5, no. 8: 2836-2859.

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