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Iron Deprivation in Cancer––Potential Therapeutic Implications
Division of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
* Author to whom correspondence should be addressed.
Received: 4 June 2013; in revised form: 12 July 2013 / Accepted: 16 July 2013 / Published: 24 July 2013
Abstract: Iron is essential for normal cellular function. It participates in a wide variety of cellular processes, including cellular respiration, DNA synthesis, and macromolecule biosynthesis. Iron is required for cell growth and proliferation, and changes in intracellular iron availability can have significant effects on cell cycle regulation, cellular metabolism, and cell division. Perhaps not surprisingly then, neoplastic cells have been found to have higher iron requirements than normal, non-malignant cells. Iron depletion through chelation has been explored as a possible therapeutic intervention in a variety of cancers. Here, we will review iron homeostasis in non-malignant and malignant cells, the widespread effects of iron depletion on the cell, the various iron chelators that have been explored in the treatment of cancer, and the tumor types that have been most commonly studied in the context of iron chelation.
Keywords: iron; chelation; cancer; leukemia; neuroblastoma; ribonucleotide reductase
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MDPI and ACS Style
Heath, J.L.; Weiss, J.M.; Lavau, C.P.; Wechsler, D.S. Iron Deprivation in Cancer––Potential Therapeutic Implications. Nutrients 2013, 5, 2836-2859.
Heath JL, Weiss JM, Lavau CP, Wechsler DS. Iron Deprivation in Cancer––Potential Therapeutic Implications. Nutrients. 2013; 5(8):2836-2859.
Heath, Jessica L.; Weiss, Joshua M.; Lavau, Catherine P.; Wechsler, Daniel S. 2013. "Iron Deprivation in Cancer––Potential Therapeutic Implications." Nutrients 5, no. 8: 2836-2859.