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Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame
Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada
* Author to whom correspondence should be addressed.
Received: 30 May 2013; in revised form: 17 July 2013 / Accepted: 17 July 2013 / Published: 23 July 2013
Abstract: Baculoviruses are one of the largest viruses that replicate in the nucleus of their host cells. During infection, the rod-shape, 250-nm long nucleocapsid delivers its genome into the nucleus. Electron microscopy evidence suggests that baculoviruses, specifically the Alphabaculoviruses (nucleopolyhedroviruses) and the Betabaculoviruses (granuloviruses), have evolved two very distinct modes for doing this. Here we review historical and current experimental results of baculovirus nuclear import studies, with an emphasis on electron microscopy studies employing the prototypical baculovirus Autographa californica multiple nucleopolyhedrovirus infecting cultured cells. We also discuss the implications of recent studies towards theories of nuclear transport mechanisms.
Keywords: baculovirus; AcMNPV; nuclear import; nuclear pore complex; viruses
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MDPI and ACS Style
Au, S.; Wu, W.; Panté, N. Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame. Viruses 2013, 5, 1885-1900.
Au S, Wu W, Panté N. Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame. Viruses. 2013; 5(7):1885-1900.
Au, Shelly; Wu, Wei; Panté, Nelly. 2013. "Baculovirus Nuclear Import: Open, Nuclear Pore Complex (NPC) Sesame." Viruses 5, no. 7: 1885-1900.