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Viruses 2013, 5(8), 1901-1923; doi:10.3390/v5081901
Review

Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein: Exploiting All Stages of Viral mRNA Processing

, ,  and *
Received: 18 June 2013; in revised form: 16 July 2013 / Accepted: 19 July 2013 / Published: 26 July 2013
(This article belongs to the Special Issue Viral Nuclear Import)
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Abstract: Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ribonucleoprotein particle. Many viruses replicate in the nucleus of the host cell and require cellular mRNA export factors to efficiently export viral transcripts. However, some viral mRNAs undergo aberrant mRNA processing, thus prompting the viruses to express their own specific mRNA export proteins to facilitate efficient export of viral transcripts and allowing translation in the cytoplasm. This review will focus on the Kaposi’s sarcoma-associated herpesvirus ORF57 protein, a multifunctional protein involved in all stages of viral mRNA processing and that is essential for virus replication. Using the example of ORF57, we will describe cellular bulk mRNA export pathways and highlight their distinct features, before exploring how the virus has evolved to exploit these mechanisms.
Keywords: KSHV; herpesvirus; ORF57; TREX; mRNA export; mRNA stability KSHV; herpesvirus; ORF57; TREX; mRNA export; mRNA stability
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Schumann, S.; Jackson, B.R.; Baquero-Perez, B.; Whitehouse, A. Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein: Exploiting All Stages of Viral mRNA Processing. Viruses 2013, 5, 1901-1923.

AMA Style

Schumann S, Jackson BR, Baquero-Perez B, Whitehouse A. Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein: Exploiting All Stages of Viral mRNA Processing. Viruses. 2013; 5(8):1901-1923.

Chicago/Turabian Style

Schumann, Sophie; Jackson, Brian R.; Baquero-Perez, Belinda; Whitehouse, Adrian. 2013. "Kaposi’s Sarcoma-Associated Herpesvirus ORF57 Protein: Exploiting All Stages of Viral mRNA Processing." Viruses 5, no. 8: 1901-1923.



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