Special Issue "Viral Nuclear Import"

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A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: 31 May 2013

Special Issue Editors

Guest Editor
Dr. Ariberto Fassati
University College London, Wohl Virion Centre, The Cruciform Building, Gower Street, London WC1E 6BT, UK
Website: https://iris.ucl.ac.uk/iris/browse/profile?upi=AFASS84
E-Mail: a.fassati@ucl.ac.uk

Co-Guest Editor
Dr. Aksana Labokha
University College London, Wohl Virion Centre, The Cruciform Building, Gower Street, London WC1E 6BT, UK
E-Mail: a.labokha@ucl.ac.uk

Special Issue Information

Dear Colleagues,

This special issue will overview mechanisms of nuclear import used by different viruses, including Adenoviruses, herpesviruses, Retroviruses, Influenza viruses, Picorna viruses etc. It will highlight both common and divergent pathways evolved by viruses to access the nucleus and how virology research has contributed to understand important basic aspects of nuclear import. We shall draw attention to the import and export of viral proteins critical for replication and to viral proteins that perturb basic nuclear import mechanisms to the advantage of the virus. We shall also explore the relationship between intacellular trafficking of viral particles, their nuclear translocation and activation of the innate immune system.

Dr. Ariberto Fassati

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs).

Keywords

  • nuclear import
  • nuclear pore
  • viruses
  • trafficking
  • nuclear transport receptors
  • nucleoporins
  • tropism

Published Papers

No papers have been published in this special issue yet, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Review
Title: Viral Subversion of the Nuclear Pore Complex
Authors: Valerie Le Sage and Andrew J. Mouland
Affiliation: Lady Davis Institute at the Jewish General Hospital and The Department of Medicine, McGill University, Montreal, Quebec, H3T 1E2 Canada
Abstract: The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to trafficking viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.

Title: Nucleocytoplasmic Trafficking of Viral Molecules in Borna Disease Virus Infection
Authors: Tomoyuki Honda and Keizo Tomonaga
Affiliation: Department of Viral Oncology, Institute for Virus Research (IVR), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Abstract: Nuclear import and export of the viral RNA and proteins are critical to the life cycle of viruses that replicate in the nucleus. Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that belongs to the order Mononegavirales. BDV has several distinguishing features. One of most striking characteristics is the site of its replication. BDV RNA is transcribed and replicated in the nucleus, while most of other negative-strand RNA viruses replicate in the cytoplasm. Therefore, the nucleocytoplasmic trafficking of BDV macromolecules plays a key role in the virus life cycle. Growing evidence indicates that several BDV proteins, including the nucleoprotein, phosphoprotein, and protein X, contribute to the nucleocytoplasmic trafficking of BDV ribonucleoprotein (RNP). The directional control of the BDV RNP trafficking is likely determined by the ratios and interactions between viral and host molecules. In this review, we present comprehensive view of several unique mechanisms that BDV has developed to control its RNP trafficking and discuss the significance of the BDV RNP trafficking in its life cycle.

Last update: 3 April 2013

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