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Viruses 2013, 5(7), 1824-1849; doi:10.3390/v5071824

Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
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Received: 10 June 2013 / Revised: 27 June 2013 / Accepted: 11 July 2013 / Published: 18 July 2013
(This article belongs to the Special Issue Viral Nuclear Import)
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Abstract

Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses. View Full-Text
Keywords: virus; influenza virus; vesicular stomatitis virus; VSV; NS1; matrix protein; nuclear export; nucleo-cytoplasmic trafficking; mRNA export; NXF1; TAP; CRM1; Rae1 virus; influenza virus; vesicular stomatitis virus; VSV; NS1; matrix protein; nuclear export; nucleo-cytoplasmic trafficking; mRNA export; NXF1; TAP; CRM1; Rae1
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kuss, S.K.; Mata, M.A.; Zhang, L.; Fontoura, B.M.A. Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export. Viruses 2013, 5, 1824-1849.

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