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Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
* Author to whom correspondence should be addressed.
Received: 10 June 2013; in revised form: 27 June 2013 / Accepted: 11 July 2013 / Published: 18 July 2013
Abstract: Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.
Keywords: virus; influenza virus; vesicular stomatitis virus; VSV; NS1; matrix protein; nuclear export; nucleo-cytoplasmic trafficking; mRNA export; NXF1; TAP; CRM1; Rae1
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Cite This Article
MDPI and ACS Style
Kuss, S.K.; Mata, M.A.; Zhang, L.; Fontoura, B.M.A. Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export. Viruses 2013, 5, 1824-1849.
Kuss SK, Mata MA, Zhang L, Fontoura BMA. Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export. Viruses. 2013; 5(7):1824-1849.
Kuss, Sharon K.; Mata, Miguel A.; Zhang, Liang; Fontoura, Beatriz M.A. 2013. "Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export." Viruses 5, no. 7: 1824-1849.