Next Article in Journal
Bromodomain Proteins in HIV Infection
Previous Article in Journal
Simian Foamy Virus in Non-Human Primates and Cross-Species Transmission to Humans in Gabon: An Emerging Zoonotic Disease in Central Africa?
Previous Article in Special Issue
RSV Fusion: Time for a New Model
Viruses 2013, 5(6), 1553-1570; doi:10.3390/v5061553
Review

Dendritic Cells in Human Pneumovirus and Metapneumovirus Infections

1,2
Received: 1 May 2013 / Revised: 24 May 2013 / Accepted: 6 June 2013 / Published: 20 June 2013
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
View Full-Text   |   Download PDF [1968 KB, 12 May 2015; original version 12 May 2015]   |   Browse Figures

Abstract

Lung dendritic cells (DC) play a fundamental role in sensing invading pathogens, as well as in the control of tolerogenic responses in the respiratory tract. Their strategic localization at the site of pathogen entry makes them particularly susceptible to initial viral invasion. Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) belong to the Paramyxoviridae family, within the Pneumovirus and Metapneumovirus genera, respectively. hRSV and hMPV are significant human respiratory pathogens that cause similar clinical manifestations and affect many of the same subpopulations. However, they differentially activate the host immune response, including DC, which represents a fundamental link between the innate and adaptive immune response. In this review, the role of DC in the immune response against hRSV and hMPV infections, as well as the inhibitory effects of these paramyxoviruses on the DC immunity will be discussed.
Keywords: dendritic cells; human metapneumovirus; respiratory syncytial virus; lung; paramyxovirus dendritic cells; human metapneumovirus; respiratory syncytial virus; lung; paramyxovirus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Guerrero-Plata, A. Dendritic Cells in Human Pneumovirus and Metapneumovirus Infections. Viruses 2013, 5, 1553-1570.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert