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Viruses 2013, 5(6), 1553-1570; doi:10.3390/v5061553

Dendritic Cells in Human Pneumovirus and Metapneumovirus Infections

Received: 1 May 2013 / Revised: 24 May 2013 / Accepted: 6 June 2013 / Published: 20 June 2013
(This article belongs to the Special Issue Pneumoviruses and Metapneumoviruses)
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Lung dendritic cells (DC) play a fundamental role in sensing invading pathogens, as well as in the control of tolerogenic responses in the respiratory tract. Their strategic localization at the site of pathogen entry makes them particularly susceptible to initial viral invasion. Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) belong to the Paramyxoviridae family, within the Pneumovirus and Metapneumovirus genera, respectively. hRSV and hMPV are significant human respiratory pathogens that cause similar clinical manifestations and affect many of the same subpopulations. However, they differentially activate the host immune response, including DC, which represents a fundamental link between the innate and adaptive immune response. In this review, the role of DC in the immune response against hRSV and hMPV infections, as well as the inhibitory effects of these paramyxoviruses on the DC immunity will be discussed.
Keywords: dendritic cells; human metapneumovirus; respiratory syncytial virus; lung; paramyxovirus dendritic cells; human metapneumovirus; respiratory syncytial virus; lung; paramyxovirus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Guerrero-Plata, A. Dendritic Cells in Human Pneumovirus and Metapneumovirus Infections. Viruses 2013, 5, 1553-1570.

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