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Viruses 2009, 1(3), 760-779; doi:10.3390/v1030760
Review

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses

 and *
Received: 18 August 2009; in revised form: 4 November 2009 / Accepted: 5 November 2009 / Published: 5 November 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
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Abstract: The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency. Although a variety of gene products are expressed from this region, the 72-kDa IE1 and the 86-kDa IE2 nuclear phosphoproteins are the most abundant and important. Both proteins have long been recognized as promiscuous transcriptional regulators. More recently, a critical role of the IE1 and IE2 proteins in counteracting nonadaptive host cell defense mechanisms has been revealed. In this review we will briefly summarize the available literature on IE1- and IE2-dependent mechanisms contributing to CMV evasion from intrinsic and innate immune responses.
Keywords: cytomegalovirus; CMV; innate immunity; intrinsic defense; interferon response; nuclear domain 10; apoptosis; immediate-early genes; IE1; IE2 cytomegalovirus; CMV; innate immunity; intrinsic defense; interferon response; nuclear domain 10; apoptosis; immediate-early genes; IE1; IE2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Paulus, C.; Nevels, M. The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses. Viruses 2009, 1, 760-779.

AMA Style

Paulus C, Nevels M. The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses. Viruses. 2009; 1(3):760-779.

Chicago/Turabian Style

Paulus, Christina; Nevels, Michael. 2009. "The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses." Viruses 1, no. 3: 760-779.



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