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Viruses 2009, 1(3), 760-779; doi:10.3390/v1030760

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses

Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg, Germany
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Received: 18 August 2009 / Revised: 4 November 2009 / Accepted: 5 November 2009 / Published: 5 November 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
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Abstract

The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency. Although a variety of gene products are expressed from this region, the 72-kDa IE1 and the 86-kDa IE2 nuclear phosphoproteins are the most abundant and important. Both proteins have long been recognized as promiscuous transcriptional regulators. More recently, a critical role of the IE1 and IE2 proteins in counteracting nonadaptive host cell defense mechanisms has been revealed. In this review we will briefly summarize the available literature on IE1- and IE2-dependent mechanisms contributing to CMV evasion from intrinsic and innate immune responses.
Keywords: cytomegalovirus; CMV; innate immunity; intrinsic defense; interferon response; nuclear domain 10; apoptosis; immediate-early genes; IE1; IE2 cytomegalovirus; CMV; innate immunity; intrinsic defense; interferon response; nuclear domain 10; apoptosis; immediate-early genes; IE1; IE2
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Paulus, C.; Nevels, M. The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses. Viruses 2009, 1, 760-779.

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