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Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus
Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 A, 00250 Helsinki, Finland
Department of Medical Microbiology and Immunology, Aarhus University, The Bartholin Building, 8000 Aarhus C, Denmark
* Author to whom correspondence should be addressed.
Received: 17 August 2009; in revised form: 3 November 2009 / Accepted: 5 November 2009 / Published: 5 November 2009
Abstract: Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the virus and the immune response, and a shift in this delicate balance either restricts the virus or enhances virus spread and tissue damage. Therefore, understanding of the cytokine response generated after HSV infection and the underlying virus-cell interactions is essential to improve our understanding of viral pathogenesis. This review summarizes the current knowledge on induction and evasion of the innate immune response by HSV.
Keywords: herpes simplex virus; evasion; innate; interferon; viral immunity
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MDPI and ACS Style
Melchjorsen, J.; Matikainen, S.; Paludan, S.R. Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus. Viruses 2009, 1, 737-759.
Melchjorsen J, Matikainen S, Paludan SR. Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus. Viruses. 2009; 1(3):737-759.
Melchjorsen, Jesper; Matikainen, Sampsa; Paludan, Søren R. 2009. "Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus." Viruses 1, no. 3: 737-759.