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Liver Cell Transformation in Chronic HBV Infection
Oncogenesis and Molecular Virology Unit, Institut Pasteur, Inserm U579, 28 rue du Dr. Roux, 75724 Paris cedex 15, France
* Author to whom correspondence should be addressed.
Received: 27 July 2009; in revised form: 26 October 2009 / Accepted: 29 October 2009 / Published: 30 October 2009
Abstract: Epidemiological studies have provided overwhelming evidence for a causal role of chronic HBV infection in the development of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying virally-induced tumorigenesis remain largely debated. In the absence of a dominant oncogene encoded by the HBV genome, indirect roles have been proposed, including insertional activation of cellular oncogenes by HBV DNA integration, induction of genetic instability by viral integration or by the regulatory protein HBx, and long term effects of viral proteins in enhancing immune-mediated liver disease. In this chapter, we discuss different models of HBV-mediated liver cell transformation based on animal systems of hepadnavirus infection as well as functional studies in hepatocyte and hepatoma cell lines. These studies might help identifying the cellular effectors connecting HBV infection and liver cell transformation.
Keywords: hepatitis B virus; hepatocellular carcinoma; HBx; pathogenesis; transformation
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Benhenda, S.; Cougot, D.; Neuveut, C.; Buendia, M.A. Liver Cell Transformation in Chronic HBV Infection. Viruses 2009, 1, 630-646.
Benhenda S, Cougot D, Neuveut C, Buendia MA. Liver Cell Transformation in Chronic HBV Infection. Viruses. 2009; 1(3):630-646.
Benhenda, Shirine; Cougot, Delphine; Neuveut, Christine; Buendia, Marie A. 2009. "Liver Cell Transformation in Chronic HBV Infection." Viruses 1, no. 3: 630-646.