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Adaptive Immunity to Hepatitis C Virus
Viruses 2009, 1(3), 484-509; doi:10.3390/v1030484

HBV and HCV Therapy

* , ,  and
“A.M. Migliavacca” Center for Liver Disease, First Gastroenterology Unit, Fondazione IRCCS Maggiore Hospital, Mangiagalli e Regina Elena, Università di Milano, Via F. Sforza 35, 20122 Milan, Italy
* Author to whom correspondence should be addressed.
Received: 13 August 2009 / Revised: 8 October 2009 / Accepted: 19 October 2009 / Published: 22 October 2009
(This article belongs to the Special Issue Hepatitis Viruses)
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One year of interferon therapy inhibits HBV replication in one third of the patients whereas long-term administration of oral nucleos(t)ide analogues is efficient in most of them, as long as early treatment adaptation in patients with partial virological response and resistance is provided. Following the demonstration of a more potent antiviral effect in terms of sustained virological response (SVR) rates, Pegylated-IFN coupled with Ribavirin has become the standard treatment for chronic hepatitis C, with nearly 65% of all treated patients achieving a SVR. Long-term suppression of HBV and eradication of HCV would halt the progression of chronic hepatitis to cirrhosis, hepatocellular carcinoma and liver decompensation.
Keywords: HBV DNA; nucleos(t)ide analogues; Peg-IFN; resistance; HCV RNA; Ribavirin; SVR HBV DNA; nucleos(t)ide analogues; Peg-IFN; resistance; HCV RNA; Ribavirin; SVR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lampertico, P.; Aghemo, A.; Viganò, M.; Colombo, M. HBV and HCV Therapy. Viruses 2009, 1, 484-509.

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