Viruses 2009, 1(3), 647-656; doi:10.3390/v1030647

Seroconversion to HCoV-NL63 in Rhesus Macaques

1 Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity (CINIMA), Academic Medical Centre (AMC), University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands 2 Department of Virology, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 139, 2280 GH, Rijswijk, The Netherlands
* Author to whom correspondence should be addressed.
Received: 26 August 2009; in revised form: 28 October 2009 / Accepted: 30 October 2009 / Published: 30 October 2009
(This article belongs to the Special Issue Newly Identified Respiratory Viruses)
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Abstract: HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.
Keywords: HCoV-NL63; rhesus macaques

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MDPI and ACS Style

Dijkman, R.; Mulder, H.L.; Rumping, L.; Kraaijvanger, I.; Deijs, M.; Jebbink, M.F.; Verschoor, E.J.; Van der Hoek, L. Seroconversion to HCoV-NL63 in Rhesus Macaques. Viruses 2009, 1, 647-656.

AMA Style

Dijkman R, Mulder HL, Rumping L, Kraaijvanger I, Deijs M, Jebbink MF, Verschoor EJ, Van der Hoek L. Seroconversion to HCoV-NL63 in Rhesus Macaques. Viruses. 2009; 1(3):647-656.

Chicago/Turabian Style

Dijkman, Ronald; Mulder, H. Lie; Rumping, Lynne; Kraaijvanger, Ilse; Deijs, Martin; Jebbink, Maarten F.; Verschoor, Ernst J.; Van der Hoek, Lia. 2009. "Seroconversion to HCoV-NL63 in Rhesus Macaques." Viruses 1, no. 3: 647-656.

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