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Seroconversion to HCoV-NL63 in Rhesus Macaques
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity (CINIMA), Academic Medical Centre (AMC), University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Department of Virology, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 139, 2280 GH, Rijswijk, The Netherlands
* Author to whom correspondence should be addressed.
Received: 26 August 2009; in revised form: 28 October 2009 / Accepted: 30 October 2009 / Published: 30 October 2009
Abstract: HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.
Keywords: HCoV-NL63; rhesus macaques
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MDPI and ACS Style
Dijkman, R.; Mulder, H.L.; Rumping, L.; Kraaijvanger, I.; Deijs, M.; Jebbink, M.F.; Verschoor, E.J.; Van der Hoek, L. Seroconversion to HCoV-NL63 in Rhesus Macaques. Viruses 2009, 1, 647-656.
Dijkman R, Mulder HL, Rumping L, Kraaijvanger I, Deijs M, Jebbink MF, Verschoor EJ, Van der Hoek L. Seroconversion to HCoV-NL63 in Rhesus Macaques. Viruses. 2009; 1(3):647-656.
Dijkman, Ronald; Mulder, H. Lie; Rumping, Lynne; Kraaijvanger, Ilse; Deijs, Martin; Jebbink, Maarten F.; Verschoor, Ernst J.; Van der Hoek, Lia. 2009. "Seroconversion to HCoV-NL63 in Rhesus Macaques." Viruses 1, no. 3: 647-656.