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Alphaviruses in Gene Therapy
Viruses 2009, 1(3), 594-629; doi:10.3390/v1030594

Herpes Virus Amplicon Vectors

Received: 30 September 2009 / Revised: 26 October 2009 / Accepted: 29 October 2009 / Published: 29 October 2009
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
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Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing.
Keywords: herpes simplex virus; HSV amplicon; gene transfer; immunotherapy; integration herpes simplex virus; HSV amplicon; gene transfer; immunotherapy; integration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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De Silva, S.; Bowers, W.J. Herpes Virus Amplicon Vectors. Viruses 2009, 1, 594-629.

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