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Viruses 2009, 1(3), 594-629; doi:10.3390/v1030594

Herpes Virus Amplicon Vectors

1
Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
2
Center for Neural Development and Disease, University of Rochester, Rochester, NY 14642, USA
3
School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
4
Department of Neurology, University of Rochester, Rochester, NY 14642, USA
5
Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
*
Author to whom correspondence should be addressed.
Received: 30 September 2009 / Revised: 26 October 2009 / Accepted: 29 October 2009 / Published: 29 October 2009
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
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Abstract

Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing.
Keywords: herpes simplex virus; HSV amplicon; gene transfer; immunotherapy; integration herpes simplex virus; HSV amplicon; gene transfer; immunotherapy; integration
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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De Silva, S.; Bowers, W.J. Herpes Virus Amplicon Vectors. Viruses 2009, 1, 594-629.

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