Herpes Virus Amplicon Vectors
AbstractSince its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing.
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De Silva, S.; Bowers, W.J. Herpes Virus Amplicon Vectors. Viruses 2009, 1, 594-629.
De Silva S, Bowers WJ. Herpes Virus Amplicon Vectors. Viruses. 2009; 1(3):594-629.Chicago/Turabian Style
De Silva, Suresh; Bowers, William J. 2009. "Herpes Virus Amplicon Vectors." Viruses 1, no. 3: 594-629.