Next Article in Journal
Food Patterns According to Sociodemographics, Physical Activity, Sleeping and Obesity in Portuguese Children
Next Article in Special Issue
A Multidisciplinary Investigation of a Polycythemia Vera Cancer Cluster of Unknown Origin
Previous Article in Journal
Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma
Previous Article in Special Issue
Leg Length, Body Proportion, and Health: A Review with a Note on Beauty
Int. J. Environ. Res. Public Health 2010, 7(3), 1105-1120; doi:10.3390/ijerph7031105

Human Amebiasis: Breaking the Paradigm?

1,* , 1,2
1 Department of Experimental Medicine, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, 04510, Mexico 2 Department of Zoology, ENCB, National Polytechnic Institute (IPN), México City, 11340, Mexico 3 Department of Morphology, Laboratory of Parasitology, Federal University of Sergipe, Aracaju, Sergipe, 49100-000, Brazil 4 Department of Infectomic and Molecular Pathogenesis, (CINVESTAV), Mexico City, 07360, Mexico 5 Department of Chemistry and Biological Science, University of Sonora (UNISON), Hermosillo, Sonora, 83000, Mexico 6 Department of Parasitology, Institute for Biological Sciences, Federal University of Minas Gerais, Minas Gerais, Belo Horizonte, 31270-901, Brazil
* Author to whom correspondence should be addressed.
Received: 19 December 2009 / Revised: 2 February 2010 / Accepted: 8 March 2010 / Published: 16 March 2010
(This article belongs to the Special Issue Advances in Epidemiology)
View Full-Text   |   Download PDF [464 KB, uploaded 19 June 2014]   |  


For over 30 years it has been established that the Entamoeba histolytica protozoan included two biologically and genetically different species, one with a pathogenic phenotype called E. histolytica and the other with a non-pathogenic phenotype called Entamoeba dispar. Both of these amoebae species can infect humans. E. histolytica has been considered as a potential pathogen that can cause serious damage to the large intestine (colitis, dysentery) and other extraintestinal organs, mainly the liver (amebic liver abscess), whereas E. dispar is a species that interacts with humans in a commensal relationship, causing no symptoms or any tissue damage. This paradigm, however, should be reconsidered or re-evaluated. In the present work, we report the detection and genotyping of E. dispar sequences of DNA obtained from patients with amebic liver abscesses, including the genotyping of an isolate obtained from a Brazilian patient with a clinical diagnosis of intestinal amebiasis that was previously characterized as an E. dispar species. The genetic diversity and phylogenetic analysis performed by our group has shown the existence of several different genotypes of E. dispar that can be associated to, or be potentiality responsible for intestinal or liver tissue damage, similar to that observed with E. histolytica.
Keywords: human amebiasis; E. histolytica; E. dispar;genetic diversity; phylogeny human amebiasis; E. histolytica; E. dispar; genetic diversity; phylogeny
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material


Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Ximénez, C.; Cerritos, R.; Rojas, L.; Dolabella, S.; Morán, P.; Shibayama, M.; González, E.; Valadez, A.; Hernández, E.; Valenzuela, O.; Limón, A.; Partida, O.; Silva, E.F. Human Amebiasis: Breaking the Paradigm? Int. J. Environ. Res. Public Health 2010, 7, 1105-1120.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert