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Int. J. Environ. Res. Public Health 2010, 7(3), 1093-1104; doi:10.3390/ijerph7031093

Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma

Department of Medicine II, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
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Received: 8 February 2010 / Revised: 2 March 2010 / Accepted: 9 March 2010 / Published: 15 March 2010
(This article belongs to the Special Issue Environmental Research on Alcohol: Public Health Perspectives)
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Abstract

: In this article we provide an overview of the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion, and their possible role in alcoholic pancreatitis and pancreatic carcinoma. The data indicate that non-alcoholic constituents of beer stimulate pancreatic enzyme secretion in humans and rats, at least in part, by direct action on pancreatic acinar cells. Some non-alcoholic compounds of beer, such as quercetin, resveratrol, ellagic acid or catechins, have been shown to be protective against experimentally induced pancreatitis by inhibiting pancreatic secretion, stellate cell activation or by reducing oxidative stress. Quercetin, ellagic acid and resveratrol also show anti-carcinogenic potential in vitro and in vivo. However, beer contains many more non-alcoholic ingredients. Their relevance in beer-induced functional alterations of pancreatic cells leading to pancreatitis and pancreatic cancer in humans needs to be further evaluated.
Keywords: beer; non-alcoholic constituents; pancreatitis; pancreatic carcinoma beer; non-alcoholic constituents; pancreatitis; pancreatic carcinoma
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gerloff, A.; Singer, M.V.; Feick, P. Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma. Int. J. Environ. Res. Public Health 2010, 7, 1093-1104.

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