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Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance
Department of Biochemistry, College of Medicine, Catholic University of Korea, Seoul 137-701, Korea
Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea
* Authors to whom correspondence should be addressed.
Received: 11 July 2013; in revised form: 31 July 2013 / Accepted: 9 August 2013 / Published: 20 August 2013
Abstract: Acquisition of drug resistance leads to failure of anti-cancer treatments and therapies. Although several successive chemotherapies are available, along with efforts towards clinical applications of new anti-cancer drugs, it is generally realized that there is a long way to go to treat cancers. Resistance to anti-cancer drugs results from various factors, including genetic as well as epigenetic differences in tumors. Determining the molecular and cellular mechanisms responsible for the acquisition of drug resistance may be a helpful approach for the development of new therapeutic strategies to overcome treatment failure. Several studies have shown that the acquisition of drug resistance is tightly regulated by post-transcriptional regulators such as RNA binding proteins (RBPs) and microRNAs (miRNAs), which change the stability and translation of mRNAs encoding factors involved in cell survival, proliferation, epithelial-mesenchymal transition, and drug metabolism. Here, we review our current understanding of ribonucleoprotein complexes, including RBPs and miRNAs, which play critical roles in the acquisition of drug resistance and have potential clinical implications for cancer.
Keywords: ribonucleoprotein complex; RNA binding protein; microRNAs; drug resistance; mRNA stability; translation
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Kang, H.; Kim, C.; Lee, H.; Kim, W.; Lee, E.K. Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance. Int. J. Mol. Sci. 2013, 14, 17204-17220.
Kang H, Kim C, Lee H, Kim W, Lee EK. Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance. International Journal of Molecular Sciences. 2013; 14(8):17204-17220.
Kang, Hoin; Kim, Chongtae; Lee, Heejin; Kim, Wook; Lee, Eun K. 2013. "Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance." Int. J. Mol. Sci. 14, no. 8: 17204-17220.