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NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis
Department of Human Genetics and Public Health, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan
Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan
* Author to whom correspondence should be addressed.
Received: 1 July 2013; in revised form: 5 August 2013 / Accepted: 7 August 2013 / Published: 19 August 2013
Abstract: Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.
Keywords: NF90; double-stranded RNA binding proteins; posttranscriptional regulation; microRNA biogenesis
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Masuda, K.; Kuwano, Y.; Nishida, K.; Rokutan, K.; Imoto, I. NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis. Int. J. Mol. Sci. 2013, 14, 17111-17121.
Masuda K, Kuwano Y, Nishida K, Rokutan K, Imoto I. NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis. International Journal of Molecular Sciences. 2013; 14(8):17111-17121.
Masuda, Kiyoshi; Kuwano, Yuki; Nishida, Kensei; Rokutan, Kazuhito; Imoto, Issei. 2013. "NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis." Int. J. Mol. Sci. 14, no. 8: 17111-17121.