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Int. J. Mol. Sci. 2013, 14(8), 17193-17203; doi:10.3390/ijms140817193
Article

Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives

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Received: 8 July 2013; in revised form: 29 July 2013 / Accepted: 7 August 2013 / Published: 20 August 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4, M5 and M34 showed higher inhibitory activity against HSV-1 virus with the TC50 values being in micromole. Compounds M28, M33, and M35 showed higher inhibitory activity against influenza virus H3N2 with their TC50 values being 96.4, 71.0 and 75.4 μM, respectively. Preliminary biological activity evaluation indicated that the anti-H3N2 and anti-HSV-1 activities improved obviously through the introduction of halogen into the structure of schizonepetin.
Keywords: chizonepetin; anti-virus activity; HSV-1; H3N2 chizonepetin; anti-virus activity; HSV-1; H3N2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bao, B.; Meng, Z.; Li, N.; Meng, Z.; Zhang, L.; Cao, Y.; Yao, W.; Shan, M.; Ding, A. Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives. Int. J. Mol. Sci. 2013, 14, 17193-17203.

AMA Style

Bao B, Meng Z, Li N, Meng Z, Zhang L, Cao Y, Yao W, Shan M, Ding A. Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives. International Journal of Molecular Sciences. 2013; 14(8):17193-17203.

Chicago/Turabian Style

Bao, Beihua; Meng, Zheng; Li, Nianguang; Meng, Zhengjie; Zhang, Li; Cao, Yudan; Yao, Weifeng; Shan, Mingqiu; Ding, Anwei. 2013. "Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives." Int. J. Mol. Sci. 14, no. 8: 17193-17203.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert