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Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
* Author to whom correspondence should be addressed.
Received: 9 July 2013; in revised form: 23 July 2013 / Accepted: 25 July 2013 / Published: 5 August 2013
Abstract: Gene expression is intricately regulated at the post-transcriptional level by RNA-binding proteins (RBPs) via their interactions with pre-messenger RNA (pre-mRNA) and mRNA during development. However, very little is known about the mechanism regulating RBP activities in RNA metabolism. During the past few years, a large body of evidence has suggested that many RBPs, such as heterogeneous nuclear ribonucleoproteins (hnRNPs), undergo post-translational modification through poly(ADP-ribosyl)ation to modulate RNA processing, including splicing, polyadenylation, translation, miRNA biogenesis and rRNA processing. Accordingly, RBP poly(ADP-ribosyl)ation has been shown to be involved in stress responses, stem cell differentiation and retinal morphogenesis. Here, we summarize recent advances in understanding the biological roles of RBP poly(ADP-ribosyl)ation, as controlled by Poly(ADP-ribose) Polymerases (PARPs) and Poly(ADP-ribose) Glycohydrolase (PARG). In addition, we discuss the potential of PARP and PARG inhibitors for the treatment of RBP-related human diseases, including cancer and neurodegenerative disorders.
Keywords: Parp; Parg; poly(ADP-ribose); RNA-binding protein; RNA metabolism
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MDPI and ACS Style
Ji, Y.; Tulin, A.V. Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins. Int. J. Mol. Sci. 2013, 14, 16168-16183.
Ji Y, Tulin AV. Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins. International Journal of Molecular Sciences. 2013; 14(8):16168-16183.
Ji, Yingbiao; Tulin, Alexei V. 2013. "Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins." Int. J. Mol. Sci. 14, no. 8: 16168-16183.