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Int. J. Mol. Sci. 2013, 14(8), 16168-16183; doi:10.3390/ijms140816168
Review

Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins

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Received: 9 July 2013 / Revised: 23 July 2013 / Accepted: 25 July 2013 / Published: 5 August 2013
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Abstract

Gene expression is intricately regulated at the post-transcriptional level by RNA-binding proteins (RBPs) via their interactions with pre-messenger RNA (pre-mRNA) and mRNA during development. However, very little is known about the mechanism regulating RBP activities in RNA metabolism. During the past few years, a large body of evidence has suggested that many RBPs, such as heterogeneous nuclear ribonucleoproteins (hnRNPs), undergo post-translational modification through poly(ADP-ribosyl)ation to modulate RNA processing, including splicing, polyadenylation, translation, miRNA biogenesis and rRNA processing. Accordingly, RBP poly(ADP-ribosyl)ation has been shown to be involved in stress responses, stem cell differentiation and retinal morphogenesis. Here, we summarize recent advances in understanding the biological roles of RBP poly(ADP-ribosyl)ation, as controlled by Poly(ADP-ribose) Polymerases (PARPs) and Poly(ADP-ribose) Glycohydrolase (PARG). In addition, we discuss the potential of PARP and PARG inhibitors for the treatment of RBP-related human diseases, including cancer and neurodegenerative disorders.
Keywords: Parp; Parg; poly(ADP-ribose); RNA-binding protein; RNA metabolism Parp; Parg; poly(ADP-ribose); RNA-binding protein; RNA metabolism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ji, Y.; Tulin, A.V. Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins. Int. J. Mol. Sci. 2013, 14, 16168-16183.

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