Molecules, Volume 7, Issue 4

A syntheses of three new muramyl dipeptide (MDP) analogues related to LK 423 as potential immunomodulators are presented. The dipeptide part of the lead compound was modified by introducing a phosphonamide isostere instead of the amide bond between L...

The synthesis of an unnatural galanthamine analog is reported

We describe here the preparation of new 5-nitroimidazoles which are known to have an efficacy against metronidazole-susceptible and -resistant Giarda, Trichomonas, and Entamoeba spp. The multi-step synthesis uses electron transfer methodology.

Various mixed carbonates can be conveniently prepared in good yields using the corresponding alcohols, alkyl halides under CO₂ atmosphere in the presence of potassium carbonate or sodium carbonate and tetrabutylammonium iodide.

This work describes the synthesis of seven new platinum complexes having Nbenzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K₂[PtCl₄] with the appropriate ligand in water. These complexes are analogs of cisplatin...