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Molecules 2002, 7(4), 405-411; doi:10.3390/70400405
Article

Synthesis of Platinum Complexes from N-Benzyl-1,3-Propanediamine Derivatives, Potential Antineoplastic Agents

1,* , 1, 1, 2,3, 1 and 3
1 Departamento de Química, Universidade Federal de Juiz de Fora, 36036-330, Juiz de Fora-MG, Brazil 2 Colégio de Aplicação João XXIII, Juiz de Fora-MG, Brazil 3 Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte-MG, Brazil
* Author to whom correspondence should be addressed.
Received: 17 August 2001 / Revised: 8 April 2002 / Accepted: 30 April 2002 / Published: 30 April 2002
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Abstract

This work describes the synthesis of seven new platinum complexes having Nbenzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K2[PtCl4] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents.
Keywords: Platinum(II) complexes; N-benzyl 1; 3-propanediamine; anticancer agents Platinum(II) complexes; N-benzyl 1; 3-propanediamine; anticancer agents
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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De Almeida, M.V.; Fontes, A.P.S.; Berg, R.N.; César, E.T.; De Castro Antunes Felício, E.; De Souza Filho, J.D. Synthesis of Platinum Complexes from N-Benzyl-1,3-Propanediamine Derivatives, Potential Antineoplastic Agents. Molecules 2002, 7, 405-411.

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