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Molecules, Volume 3, Issue 3 (March 1998), Pages 51-131, Articles M49-M73

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Open AccessArticle Evaluation of Effect of Microwave Irradiation on Syntheses and Reactions of Some New 3-Acyl-methylchromones
Molecules 1998, 3(3), 120-131; https://doi.org/10.3390/30300120
Received: 16 January 1998 / Accepted: 17 February 1998 / Published: 10 March 1998
Cited by 14 | PDF Full-text (68 KB) | HTML Full-text | XML Full-text
Abstract
The 3-Acyl-2-R-methylchromones (R = H, ArO, C6H4(CO)2N) were prepared in good yields by different methods from 2-hydroxyaroylacetone derivatives. Some subsequent reactions of these compounds with hydroxylamine and 3-formylchromones are described. The effect of microwave irradation on some condensation reactions was studied. Full article
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Open AccessArticle Enantiodivergent Synthesis of (R)- and (S)-Rolipram
Molecules 1998, 3(3), 107-119; https://doi.org/10.3390/30300107
Received: 2 November 1997 / Accepted: 23 February 1998 / Published: 10 March 1998
Cited by 36 | PDF Full-text (466 KB) | HTML Full-text | XML Full-text
Abstract
Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation
[...] Read more.
Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation gave (R)-(-)-1 and (S)-(+)-1, respectively. CD spectra of both enantiomers of rolipram are reported and discussed. Both enantiomers of rolipram presented the same potency of inhibitory activity against recombinant cyclic-AMP-selective phosphodiesterase (PDE4) subtypes. Full article
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Open AccessArticle A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones
Molecules 1998, 3(3), 100-106; https://doi.org/10.3390/30300100
Received: 28 January 1998 / Accepted: 18 February 1998 / Published: 9 March 1998
Cited by 110 | PDF Full-text (41 KB) | HTML Full-text | XML Full-text
Abstract
An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones is described. The synthesis is based on the reaction of readily available α-tosyl substituted thioureas or ureas with enolates of β-oxoesters or 1,3-dicarbonyl compounds followed by acid-catalyzed dehydration of the obtained 5-acyl-4-hydroxyhexahydropyrimidine-2-thiones/ones. Full article
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Open AccessReview Elemental and Molecular Heritage: An Internet-based Display
Molecules 1998, 3(3), 94-99; https://doi.org/10.3390/30300094
Received: 3 March 1998 / Accepted: 6 March 1998 / Published: 9 March 1998
Cited by 4 | PDF Full-text (414 KB) | HTML Full-text | XML Full-text
Abstract
The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are
[...] Read more.
The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are shown, together with a recently discovered heterocyclic systems scorpionine, which like mauveine is made by a deceptively simple chemical synthesis. Full article
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Open AccessShort Note (E)-3-(2-Methoxyphenyl)-2-butenoic Acid
Molecules 1998, 3(3), M73; https://doi.org/10.3390/M73
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (Z)-3-(2-Methoxyphenyl)-2-butenoate
Molecules 1998, 3(3), M72; https://doi.org/10.3390/M72
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The synthetic procedure [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (E)-3-(2-Methoxyphenyl)-2-butenoate
Molecules 1998, 3(3), M71; https://doi.org/10.3390/M71
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note bis-[(Z)-5-Phenyl-2-penten-2-yl]mercury
Molecules 1998, 3(3), M70; https://doi.org/10.3390/M70
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note [(Z)-5-Phenyl-2-penten-2-yl]mercury Acetate
Molecules 1998, 3(3), M69; https://doi.org/10.3390/M69
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note [(Z)-5-Phenyl-2-penten-2-yl]mercury Bromide
Molecules 1998, 3(3), M68; https://doi.org/10.3390/M68
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Tributyl-[(Z)-5-phenyl-2-penten-2-yl]stannane
Molecules 1998, 3(3), M67; https://doi.org/10.3390/M67
Received: 27 February 1998 / Published: 6 March 1998
Cited by 2 | Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (Z)-2-Bromo-5-phenyl-2-pentene
Molecules 1998, 3(3), M66; https://doi.org/10.3390/M66
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2,3-Dibromo-2-methyl-5-phenylpentanoic Acid
Molecules 1998, 3(3), M65; https://doi.org/10.3390/M65
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (E)-2-Methyl-5-phenyl-2-pentenoic Acid
Molecules 1998, 3(3), M64; https://doi.org/10.3390/M64
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The general part of the experimental section [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (Z)-2-Methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M63; https://doi.org/10.3390/M63
Received: 27 February 1998 / Published: 6 March 1998
| Supplementary Files
Abstract
The synthetic procedure [1] has been presented elsewhere.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
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