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Molecules, Volume 3, Issue 3 (March 1998), Pages 51-131, Articles M49-M73

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Research

Jump to: Review, Other

Open AccessArticle Efficient Polymer-Supported Sharpless Alkene Epoxidation Catalyst
Molecules 1998, 3(3), 51-59; doi:10.3390/30300051
Received: 11 January 1998 / Accepted: 13 February 1998 / Published: 17 February 1998
Cited by 18 | PDF Full-text (46 KB)
Abstract
Homogeneous linear poly(tartrate ester) ligands provide high chemical yields and enantiomeric excesses in the epoxidation of trans-hex-2-en-1-ol using Ti(OPri)4-tert-butyl hydroperoxide. Branched poly(tartrate ester) can be use as heterogeneous ligands in the epoxidation of trans-hex-2-en-1-ol [...] Read more.
Homogeneous linear poly(tartrate ester) ligands provide high chemical yields and enantiomeric excesses in the epoxidation of trans-hex-2-en-1-ol using Ti(OPri)4-tert-butyl hydroperoxide. Branched poly(tartrate ester) can be use as heterogeneous ligands in the epoxidation of trans-hex-2-en-1-ol using Ti(OPri)4-tert-butyl hydroperoxide. Removal and recovery of the polymer catalyst is a simple filtration at the end of reactions. Full article
Open AccessArticle Intramolecular Cycloaddition of Imines of Cysteine Derivatives
Molecules 1998, 3(3), 60-63; doi:10.3390/30300060
Received: 3 December 1997 / Accepted: 3 February 1998 / Published: 18 February 1998
PDF Full-text (22 KB)
Abstract Azomethine ylides were generated from Schiffs bases of S-allylcysteine methyl ester and their intramolecular 1,3-dipolar cycloadditions were studied. These reactions led to the synthesis of thieno[3,4-b]pyrrole derivatives in good yield. Full article
Open AccessArticle An Asymmetric Synthetic Approach to the A-ring of the Taxol Family of Anti-Cancer Compounds
Molecules 1998, 3(3), 64-70; doi:10.3390/30300064
Received: 10 January 1998 / Accepted: 16 February 1998 / Published: 20 February 1998
Cited by 1 | PDF Full-text (52 KB)
Abstract
A synthetic route developed for the preparation of the A-ring of Taxol family of molecules is reported. By means of an intramolecular Diels-Alder reaction an asymmetric approach to this ring has been accomplished. Also, initial studies to prepare the A ring using [...] Read more.
A synthetic route developed for the preparation of the A-ring of Taxol family of molecules is reported. By means of an intramolecular Diels-Alder reaction an asymmetric approach to this ring has been accomplished. Also, initial studies to prepare the A ring using an intramolecular Diels-Alder reaction have been successful. Full article
Open AccessArticle Synthesis of Novel Fused Heterocycles Based on Pyrano[2,3-c]pyrazole
Molecules 1998, 3(3), 71-79; doi:10.3390/30300071
Received: 30 October 1997 / Accepted: 18 January 1998 / Published: 23 February 1998
Cited by 12 | PDF Full-text (50 KB)
Abstract
3-Substituted 1,2,4-triazole derivatives (5, 9, 13, 16b, 19), pyrimidinium salts (21), triazines (24), and aryl methylene hydrazono pyrazolopyrano-pyrimidine (27a,b) which are rearranged in basic medium to 30a,b, were afforded via the reaction of 6-amino 1,4,5,6-tetrahydro-5-imino-3-methyl-1-phenyl-4 (pchlorophenyl) pyrazolo [4', 3' : 5,6]-pyrano [2,3-d] [...] Read more.
3-Substituted 1,2,4-triazole derivatives (5, 9, 13, 16b, 19), pyrimidinium salts (21), triazines (24), and aryl methylene hydrazono pyrazolopyrano-pyrimidine (27a,b) which are rearranged in basic medium to 30a,b, were afforded via the reaction of 6-amino 1,4,5,6-tetrahydro-5-imino-3-methyl-1-phenyl-4 (pchlorophenyl) pyrazolo [4', 3' : 5,6]-pyrano [2,3-d] pyrimidine (3) with different reagents. Full article
Open AccessArticle Synthesis of (2R,5R)-2-Amino-5-Hydroxyhexanoic Acid by Intramolecular Cycloaddition
Molecules 1998, 3(3), 80-87; doi:10.3390/30300080
Received: 15 January 1998 / Accepted: 23 February 1998 / Published: 24 February 1998
Cited by 2 | PDF Full-text (43 KB)
Abstract
The title compound was synthesized from sorbic acid by an eight step sequence. The key step was the stereospecific intramolecular Diels-Alder reaction of the acylnitroso derivative of N-sorbyl-L-proline (5). L-Proline served as a temporary tether which directed both the stereochemistry and the [...] Read more.
The title compound was synthesized from sorbic acid by an eight step sequence. The key step was the stereospecific intramolecular Diels-Alder reaction of the acylnitroso derivative of N-sorbyl-L-proline (5). L-Proline served as a temporary tether which directed both the stereochemistry and the regiochemistry of the cycloaddition. Full article
Open AccessArticle Application of Microwave in Organic Synthesis. Dry Synthesis of 2-Arylmethylene-3(2)-naphthofuranones
Molecules 1998, 3(3), 88-93; doi:10.3390/30300088
Received: 19 February 1998 / Accepted: 3 March 1998 / Published: 5 March 1998
Cited by 16 | PDF Full-text (55 KB)
Abstract 3(2)-Naphthofuranone (1) was condensed in the presence of Al2O3-KF with aromatic aldehydes (4) to give arylidenenaphthofuranones (5a-f) without solvent under focused microwave irradiation. Full article
Open AccessArticle A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones
Molecules 1998, 3(3), 100-106; doi:10.3390/30300100
Received: 28 January 1998 / Accepted: 18 February 1998 / Published: 9 March 1998
Cited by 66 | PDF Full-text (41 KB)
Abstract An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones is described. The synthesis is based on the reaction of readily available α-tosyl substituted thioureas or ureas with enolates of β-oxoesters or 1,3-dicarbonyl compounds followed by acid-catalyzed dehydration of the obtained 5-acyl-4-hydroxyhexahydropyrimidine-2-thiones/ones. Full article
Open AccessArticle Enantiodivergent Synthesis of (R)- and (S)-Rolipram
Molecules 1998, 3(3), 107-119; doi:10.3390/30300107
Received: 2 November 1997 / Accepted: 23 February 1998 / Published: 10 March 1998
Cited by 25 | PDF Full-text (466 KB)
Abstract
Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular [...] Read more.
Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric amides obtained with (S)-(-)-phenylethylamine. Reduction of the nitro group and intramolecular transamidation gave (R)-(-)-1 and (S)-(+)-1, respectively. CD spectra of both enantiomers of rolipram are reported and discussed. Both enantiomers of rolipram presented the same potency of inhibitory activity against recombinant cyclic-AMP-selective phosphodiesterase (PDE4) subtypes. Full article
Open AccessArticle Evaluation of Effect of Microwave Irradiation on Syntheses and Reactions of Some New 3-Acyl-methylchromones
Molecules 1998, 3(3), 120-131; doi:10.3390/30300120
Received: 16 January 1998 / Accepted: 17 February 1998 / Published: 10 March 1998
Cited by 9 | PDF Full-text (68 KB)
Abstract The 3-Acyl-2-R-methylchromones (R = H, ArO, C6H4(CO)2N) were prepared in good yields by different methods from 2-hydroxyaroylacetone derivatives. Some subsequent reactions of these compounds with hydroxylamine and 3-formylchromones are described. The effect of microwave irradation on some condensation reactions was studied. Full article

Review

Jump to: Research, Other

Open AccessReview Elemental and Molecular Heritage: An Internet-based Display
Molecules 1998, 3(3), 94-99; doi:10.3390/30300094
Received: 3 March 1998 / Accepted: 6 March 1998 / Published: 9 March 1998
Cited by 4 | PDF Full-text (414 KB)
Abstract
The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems [...] Read more.
The background to a Web page describing elemental and molecular heritage at Imperial College chemistry department is described. Photographs are shown of the original samples of elemental bromine and crystalline silicon, and molecular ferrocene and mauveine. 3D "Hyperactive" models of these systems are shown, together with a recently discovered heterocyclic systems scorpionine, which like mauveine is made by a deceptively simple chemical synthesis. Full article

Other

Jump to: Research, Review

Open AccessShort Note Cycloartan-2b-2-methyl ButanoateIsolated from Genus Espeletia (Asteraceae)
Molecules 1998, 3(3), M49; doi:10.3390/M49
Received: 12 February 1998 / Published: 4 March 1998
PDF Full-text (117 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Methyl 2,3-O-Isopropylidene-a-D-mannofuranoside 5,6-Carbonate
Molecules 1998, 3(3), M50; doi:10.3390/M50
Received: 16 February 1998 / Published: 4 March 1998
PDF Full-text (91 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (E)-3-methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M51; doi:10.3390/M51
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (119 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (Z)-3-Methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M52; doi:10.3390/M52
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (115 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (E)-3-Methyl-5-phenyl-2-pentenoic Acid
Molecules 1998, 3(3), M53; doi:10.3390/M53
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (105 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (Z)-3-Methyl-5-phenyl-2-pentenoic Acid
Molecules 1998, 3(3), M54; doi:10.3390/M54
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (102 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2(S,R),3(R,S)-2,3-Dibromo-3-methyl-5-phenyl-2-pentanoic Acid
Molecules 1998, 3(3), M55; doi:10.3390/M55
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (103 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2(R,S),3(S,R)-2,3-Dibromo-3-methyl-5-phenyl-2-pentanoic Acid
Molecules 1998, 3(3), M56; doi:10.3390/M56
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (103 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (Z)-1-Bromo-2-methyl-4-phenyl-1-butene
Molecules 1998, 3(3), M57; doi:10.3390/M57
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (102 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (E)-1-Bromo-2-methyl-4-phenyl-1-butene
Molecules 1998, 3(3), M58; doi:10.3390/M58
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (104 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl 3-Hydroxy-3-methyl-5-phenylpentanoate
Molecules 1998, 3(3), M59; doi:10.3390/M59
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (97 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl 3-Acetoxy-3-methyl-5-phenylpentanoate
Molecules 1998, 3(3), M60; doi:10.3390/M60
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (98 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 3-Hydroxy-3-methyl-5-phenylpentanoic Acid
Molecules 1998, 3(3), M61; doi:10.3390/M61
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (97 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (E)-2-Methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M62; doi:10.3390/M62
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (116 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (Z)-2-Methyl-5-phenyl-2-pentenoate
Molecules 1998, 3(3), M63; doi:10.3390/M63
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (112 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (E)-2-Methyl-5-phenyl-2-pentenoic Acid
Molecules 1998, 3(3), M64; doi:10.3390/M64
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (104 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note 2,3-Dibromo-2-methyl-5-phenylpentanoic Acid
Molecules 1998, 3(3), M65; doi:10.3390/M65
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (96 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (Z)-2-Bromo-5-phenyl-2-pentene
Molecules 1998, 3(3), M66; doi:10.3390/M66
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (103 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Tributyl-[(Z)-5-phenyl-2-penten-2-yl]stannane
Molecules 1998, 3(3), M67; doi:10.3390/M67
Received: 27 February 1998 / Published: 6 March 1998
Cited by 2 | PDF Full-text (102 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note [(Z)-5-Phenyl-2-penten-2-yl]mercury Bromide
Molecules 1998, 3(3), M68; doi:10.3390/M68
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (99 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note [(Z)-5-Phenyl-2-penten-2-yl]mercury Acetate
Molecules 1998, 3(3), M69; doi:10.3390/M69
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (101 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note bis-[(Z)-5-Phenyl-2-penten-2-yl]mercury
Molecules 1998, 3(3), M70; doi:10.3390/M70
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (103 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (E)-3-(2-Methoxyphenyl)-2-butenoate
Molecules 1998, 3(3), M71; doi:10.3390/M71
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (119 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note Ethyl (Z)-3-(2-Methoxyphenyl)-2-butenoate
Molecules 1998, 3(3), M72; doi:10.3390/M72
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (116 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
Open AccessShort Note (E)-3-(2-Methoxyphenyl)-2-butenoic Acid
Molecules 1998, 3(3), M73; doi:10.3390/M73
Received: 27 February 1998 / Published: 6 March 1998
PDF Full-text (106 KB) | Supplementary Files
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

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