Molecules 1998, 3(3), 100-106; doi:10.3390/30300100
Article

A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones

Anatoly D. Shutalev* email, Ekaterina A. Kishko, Natalie V. Sivova and Aleksei Yu. Kuznetsov
Department of Organic Chemistry, State Academy of Fine Chemical Technology, Vernadsky Ave. 86, Moscow 117571, Russian Federation
* Author to whom correspondence should be addressed.
Received: 28 January 1998 / Accepted: 18 February 1998 / Published: 9 March 1998
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Abstract: An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones is described. The synthesis is based on the reaction of readily available α-tosyl substituted thioureas or ureas with enolates of β-oxoesters or 1,3-dicarbonyl compounds followed by acid-catalyzed dehydration of the obtained 5-acyl-4-hydroxyhexahydropyrimidine-2-thiones/ones.
Keywords: α-Tosyl substituted (thio)ureas; 5-acyl-1; 2; 3; 4-tetrahydropyrimidine-2-thiones/ones

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MDPI and ACS Style

Shutalev, A.D.; Kishko, E.A.; Sivova, N.V.; Kuznetsov, A.Y. A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones. Molecules 1998, 3, 100-106.

AMA Style

Shutalev AD, Kishko EA, Sivova NV, Kuznetsov AY. A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones. Molecules. 1998; 3(3):100-106.

Chicago/Turabian Style

Shutalev, Anatoly D.; Kishko, Ekaterina A.; Sivova, Natalie V.; Kuznetsov, Aleksei Y. 1998. "A New Convenient Synthesis of 5-Acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones." Molecules 3, no. 3: 100-106.

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