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Molecules 2016, 21(7), 899; doi:10.3390/molecules21070899

Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions

Department of Pharmacology, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
Anti-Aging Research Institute of BIO-FD & C Co. Ltd., Incheon 21990, Korea
Department of Wellness & Healthy Aging, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
Jeongseon Agricultural Extension Center, Jeongseon 26103, Korea
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Pedro Mena
Received: 19 March 2016 / Revised: 28 June 2016 / Accepted: 1 July 2016 / Published: 8 July 2016
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Skin is the outermost layer of the human body that is constantly exposed to environmental stressors, such as UV radiation and toxic chemicals, and is susceptible to mechanical wounding and injury. The ability of the skin to repair injuries is paramount for survival and it is disrupted in a spectrum of disorders leading to skin pathologies. Diabetic patients often suffer from chronic, impaired wound healing, which facilitate bacterial infections and necessitate amputation. Here, we studied the effects of gallic acid (GA, 3,4,5-trihydroxybenzoic acid; a plant-derived polyphenolic compound) on would healing in normal and hyperglucidic conditions, to mimic diabetes, in human keratinocytes and fibroblasts. Our study reveals that GA is a potential antioxidant that directly upregulates the expression of antioxidant genes. In addition, GA accelerated cell migration of keratinocytes and fibroblasts in both normal and hyperglucidic conditions. Further, GA treatment activated factors known to be hallmarks of wound healing, such as focal adhesion kinases (FAK), c-Jun N-terminal kinases (JNK), and extracellular signal-regulated kinases (Erk), underpinning the beneficial role of GA in wound repair. Therefore, our results demonstrate that GA might be a viable wound healing agent and a potential intervention to treat wounds resulting from metabolic complications. View Full-Text
Keywords: gallic acid; wound healing; cell migration; hyperglucidic condition gallic acid; wound healing; cell migration; hyperglucidic condition

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, D.J.; Moh, S.H.; Son, D.H.; You, S.; Kinyua, A.W.; Ko, C.M.; Song, M.; Yeo, J.; Choi, Y.-H.; Kim, K.W. Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions. Molecules 2016, 21, 899.

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