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Molecules 2016, 21(6), 721; doi:10.3390/molecules21060721

Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents

1
Institute of Food Science Research (CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, Spain
2
Biópolis SL, Parc Científic Universitat de Valencia, Catedrático Agustín Escardino 9, edificio 2, 46980 Valencia, Spain
3
Centro de Biología Molecular Severo Ochoa (CBM-SO) (CSIC-UAM), Nicolás Cabrera, 1, 28049 Madrid, Spain
4
Beacon Biomedicine, Parque Científico de Madrid, Santiago Grisolia 2, D130/L145, 28760 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Pedro Mena
Received: 14 April 2016 / Revised: 20 May 2016 / Accepted: 20 May 2016 / Published: 1 June 2016
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Abstract

Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector’s sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material. View Full-Text
Keywords: coffee silverskin; oxidative stress; UVC radiation; chlorogenic acid; skin health; accelerated aging; nutricosmetic; dermaceutic coffee silverskin; oxidative stress; UVC radiation; chlorogenic acid; skin health; accelerated aging; nutricosmetic; dermaceutic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Iriondo-DeHond, A.; Martorell, P.; Genovés, S.; Ramón, D.; Stamatakis, K.; Fresno, M.; Molina, A.; del Castillo, M.D. Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents. Molecules 2016, 21, 721.

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