Special Issue "New Frontiers on the Metabolism, Bioavailability and Health Effects of Phenolic Compounds"
Deadline for manuscript submissions: closed (30 June 2016)
Dr. Pedro Mena
The Special Issue “New Frontiers on the Metabolism, Bioavailability and Health Effects of Phenolic Compounds” should, with a set of fresh eyes, shed light on how (poly)phenolic substances are: (1) metabolized and turned into bioavailable molecules and (2) able to impact different biological processes related to human health. Phenolic compounds, and in particular, plant‑-derived secondary metabolites, have shown promising health promotion features in epidemiological and human intervention studies concerning the prevention of non-communicable diseases. The elucidation of the metabolic fate of (poly)phenolic constituents and their bioavailability is a tipping point for fully unraveling the bioactive(s) responsible for phenolic compounds' demonstrated preventative effects on cardiovascular diseases, metabolic syndrome, neurodegenerative disorders, and certain kinds of cancer. There is a need for addressing: (1) the colonic microbiota catabolism of phenolic compounds and (2) the inter-individual differences in bioavailability and bioefficacy due to the diversity of microbiota composition. Moreover, future research should be focused on: (1) understanding the dose/phenolic intake–response relationship via pharmacokinetic studies and (2) evaluating proper biomarkers of intake. The design of nutritionally‑ matched control/test foodstuffs is also required for conducting well-‑controlled intervention studies with both animals and human subjects. In vitro investigations using physiologically achievable concentrations of (poly)phenol phase II metabolites with appropriate model test systems are also encouraged to give adequate mechanistic insights. On the other hand, foodomics technologies (metabolomics, nutrigenomics, and proteomics) should be used to assess the role of phenolic bioactives from a comprehensive perspective. Likewise, any novel food-processing approach trying to enhance the bioavailability of (poly)phenols or sticking to what really happens after phenolic consumption should be taken into consideration. Finally, new communication channels and educational programs that are able to bring to the general public the well-defined biological properties of phenolics should be implemented. In conclusion, this Special Issue should review all the aspects concerning the metabolism, bioavailability, and biological properties of (poly)phenolic compounds and discuss attempts to solve current critical gaps. Novel methodologies or out of the box approaches can also complement current knowledge and assist in the study of plant bioactives.
Dr. Rafael Llorach
Dr. Pedro Mena
Manuscript Submission Information
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- Phenolic compounds Dietary plant bioactives Colonic catabolism Phase II metabolites Gut microbiota Bioavailability Bioactivity Human intervention trials Metabolomics