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Molecules 2016, 21(4), 512; doi:10.3390/molecules21040512

MP-V1 from the Venom of Social Wasp Vespula vulgaris Is a de Novo Type of Mastoparan that Displays Superior Antimicrobial Activities

1
National Institute of Biological Resources (NIBR), Environmental Research Complex, Incheon 404-708, Korea
2
Division of Applied Life Science (BK21 Plus) & Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju 660-701, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Mary Fletcher
Received: 30 January 2016 / Revised: 19 March 2016 / Accepted: 12 April 2016 / Published: 19 April 2016
(This article belongs to the Special Issue Natural Toxins)
View Full-Text   |   Download PDF [1473 KB, uploaded 19 April 2016]   |  

Abstract

Mastoparans from the venom of social wasps have attracted considerable attention as effective antibiotic candidates. In this study, mastoparan V1 (MP-V1) from Vespula vulgaris was first disclosed to have a peptide amino acid sequence distinct from typical mastoparans and its biochemical properties and antimicrobial effects were compared with those of typical mastoparans MP-L, -X(V) and -B. Circular dichroism (CD) spectroscopy revealed that MP-V1 and -X(V) form more stable α-helical conformations in lipid membrane-like environments than MP-L and -B. In parallel, these two also showed more effective antimicrobial activities against the pathogens than did MP-L and -B. Although MP-V1 had a less stable α-helical conformation than MP-X(V), it showed stronger antimicrobial effects against Streptococcus mutans and Salmonella enterica than MP-X(V). In the meantime, analysis of hemolytic activity revealed a range of doses (~50 μM) that exhibited little potent cytotoxicity on human erythrocytes. Finally, the atypical MP-V1 peptide amino acid sequence provided important clues to understanding its antimicrobial mechanism from a structural perspective. Therefore, it has been concluded that MP-V1 is a de novo type of mastoparan with superior antimicrobial activities against both pathogenic bacteria and fungi, which may be useful in developing multipurpose antimicrobial drugs against infectious diseases. View Full-Text
Keywords: antimicrobial activity; mastoparan; MP-V1; peptide; venom; wasp antimicrobial activity; mastoparan; MP-V1; peptide; venom; wasp
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, Y.; Son, M.; Noh, E.-Y.; Kim, S.; Kim, C.; Yeo, J.-H.; Park, C.; Lee, K.W.; Bang, W.Y. MP-V1 from the Venom of Social Wasp Vespula vulgaris Is a de Novo Type of Mastoparan that Displays Superior Antimicrobial Activities. Molecules 2016, 21, 512.

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