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Molecules 2016, 21(4), 515; doi:10.3390/molecules21040515

Two New Bioactive α-Pyrones from Hypericum japonicum

1
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
2
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 18 March 2016 / Revised: 31 March 2016 / Accepted: 16 April 2016 / Published: 19 April 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1206 KB, uploaded 19 April 2016]   |  

Abstract

Hypericum japonicum (Guttiferae), a type of annual or perennial herb, has been historically applied to cure infectious hepatitis, acute and chronic hepatitis, gastrointestinal disorder, and internal hemorrhage. In our successive studies on the genus Hypericum, two new α-pyrones termed japopyrones A and B (1 and 2) were isolated from H. japonicum. Their structures and absolute configurations were established by the comprehensive analyses of spectroscopic data, the application of the Single-crystal X-ray diffraction structural analysis, and the experimental electronic circular dichroism (ECD) spectra. Bioactivity screenings suggested that compound 2 possessed the potential inhibition efficacy on lytic replication of Kaposi’s sarcoma associated herpesvirus (KSHV) with an IC50 29.46 μM and a selective index of higher than 6.79, respectively. View Full-Text
Keywords: Hypericum japonicum; pyrones; Kaposi’s sarcoma associated herpes virus Hypericum japonicum; pyrones; Kaposi’s sarcoma associated herpes virus
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Hu, L.; Wang, Z.; Zhang, J.; Lu, Y.; Wang, K.; Xue, Y.; Zhang, Y.; Zhang, Y. Two New Bioactive α-Pyrones from Hypericum japonicum. Molecules 2016, 21, 515.

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