Two New Bioactive α-Pyrones from Hypericum japonicum
AbstractHypericum japonicum (Guttiferae), a type of annual or perennial herb, has been historically applied to cure infectious hepatitis, acute and chronic hepatitis, gastrointestinal disorder, and internal hemorrhage. In our successive studies on the genus Hypericum, two new α-pyrones termed japopyrones A and B (1 and 2) were isolated from H. japonicum. Their structures and absolute configurations were established by the comprehensive analyses of spectroscopic data, the application of the Single-crystal X-ray diffraction structural analysis, and the experimental electronic circular dichroism (ECD) spectra. Bioactivity screenings suggested that compound 2 possessed the potential inhibition efficacy on lytic replication of Kaposi’s sarcoma associated herpesvirus (KSHV) with an IC50 29.46 μM and a selective index of higher than 6.79, respectively. View Full-Text
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Hu, L.; Wang, Z.; Zhang, J.; Lu, Y.; Wang, K.; Xue, Y.; Zhang, Y.; Zhang, Y. Two New Bioactive α-Pyrones from Hypericum japonicum. Molecules 2016, 21, 515.
Hu L, Wang Z, Zhang J, Lu Y, Wang K, Xue Y, Zhang Y, Zhang Y. Two New Bioactive α-Pyrones from Hypericum japonicum. Molecules. 2016; 21(4):515.Chicago/Turabian Style
Hu, Linzhen; Wang, Zhenzhen; Zhang, Jinwen; Lu, Yuanyuan; Wang, Kaiping; Xue, Yongbo; Zhang, Yu; Zhang, Yonghui. 2016. "Two New Bioactive α-Pyrones from Hypericum japonicum." Molecules 21, no. 4: 515.
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