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Molecules 2015, 20(6), 11554-11568; doi:10.3390/molecules200611554

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

1
Laboratory of Molecular Immunology and Parasitology, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain
3
Department of Pharmaceutical Sciences, Faculty of Sciences, Catholic University of the North, 0610-Antofagasta, Chile
4
Department of Parasitology, Faculty of Pharmacy, Complutense University of Madrid (CEI Campus Moncloa, UCM-UPM & CSIC), 28040-Madrid, Spain
5
Research Center on Health for the Tropics, (CIST), Carretera Troncal del Caribe, Sector Mamatoco, Santa Marta, Magdalena, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Christophe Dardonville
Received: 15 April 2015 / Revised: 16 June 2015 / Accepted: 17 June 2015 / Published: 23 June 2015
(This article belongs to the Special Issue Antiparasitic Agents)
View Full-Text   |   Download PDF [728 KB, uploaded 23 June 2015]   |  

Abstract

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54. View Full-Text
Keywords: aminoalcohols; diamines; Trypanosoma cruzi; epimastigotes; amastigotes; cytotoxicity aminoalcohols; diamines; Trypanosoma cruzi; epimastigotes; amastigotes; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Legarda-Ceballos, A.L.; del Olmo, E.; López-Abán, J.; Escarcena, R.; Bustos, L.A.; Fonseca-Berzal, C.; Gómez-Barrio, A.; Dib, J.C.; Feliciano, A.S.; Muro, A. Trypanocidal Activity of Long Chain Diamines and Aminoalcohols. Molecules 2015, 20, 11554-11568.

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