Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
AbstractThirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54. View Full-Text
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Legarda-Ceballos, A.L.; del Olmo, E.; López-Abán, J.; Escarcena, R.; Bustos, L.A.; Fonseca-Berzal, C.; Gómez-Barrio, A.; Dib, J.C.; Feliciano, A.S.; Muro, A. Trypanocidal Activity of Long Chain Diamines and Aminoalcohols. Molecules 2015, 20, 11554-11568.
Legarda-Ceballos AL, del Olmo E, López-Abán J, Escarcena R, Bustos LA, Fonseca-Berzal C, Gómez-Barrio A, Dib JC, Feliciano AS, Muro A. Trypanocidal Activity of Long Chain Diamines and Aminoalcohols. Molecules. 2015; 20(6):11554-11568.Chicago/Turabian Style
Legarda-Ceballos, Ana L.; del Olmo, Esther; López-Abán, Julio; Escarcena, Ricardo; Bustos, Luis A.; Fonseca-Berzal, Cristina; Gómez-Barrio, Alicia; Dib, Juan C.; Feliciano, Arturo S.; Muro, Antonio. 2015. "Trypanocidal Activity of Long Chain Diamines and Aminoalcohols." Molecules 20, no. 6: 11554-11568.