Next Article in Journal
Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
Next Article in Special Issue
Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives
Previous Article in Journal
Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro
Previous Article in Special Issue
Synthesis, Characterization, Antimicrobial Screening and Free-Radical Scavenging Activity of Some Novel Substituted Pyrazoles
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(6), 11535-11553; doi:10.3390/molecules200611535

Uses of 3-(2-Bromoacetyl)-2H-chromen-2-one in the Synthesis of Heterocyclic Compounds Incorporating Coumarin: Synthesis, Characterization and Cytotoxicity

1
Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt
2
Chemistry Department, Faculty of Education, Alexandria University, Alexandria 21526, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Richard A. Bunce
Received: 1 June 2015 / Revised: 17 June 2015 / Accepted: 18 June 2015 / Published: 23 June 2015
(This article belongs to the Collection Heterocyclic Compounds)
View Full-Text   |   Download PDF [1313 KB, uploaded 23 June 2015]   |  

Abstract

In this work, 3-bromoacetylcoumarin was used as the key starting material for the synthesis of pyran, pyridine, thiophene, thiazole and pyrazole derivatives through its reaction with different reagents. The structures of the newly synthesized compounds were confirmed on the basis of their spectral data and elemental analyses. All of the synthesized compounds were screened for their in vitro anticancer activity against six human cancer cell lines, namely: human gastric cancer (NUGC), human colon cancer (DLD1), human liver cancer (HA22T and HEPG2), nasopharyngeal carcinoma (HONE1), human breast cancer (MCF) and normal fibroblast cells (WI38). The IC50 values (the sample concentration that produces 50% reduction in cell growth) in nanomolars (nM)) showed most of the compounds exhibited significant cytotoxic effect. Among these derivatives, compound 6d showed almost equipotent cytotoxic activity against NUGC (IC50 = 29 nM) compared to the standard CHS 828 (IC50 = 25 nM). View Full-Text
Keywords: coumarin; pyran; pyridine; thiazole; pyrazole; cytotoxicity coumarin; pyran; pyridine; thiazole; pyrazole; cytotoxicity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mohareb, R.M.; MegallyAbdo, N.Y. Uses of 3-(2-Bromoacetyl)-2H-chromen-2-one in the Synthesis of Heterocyclic Compounds Incorporating Coumarin: Synthesis, Characterization and Cytotoxicity. Molecules 2015, 20, 11535-11553.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top