Next Article in Journal
Synthesis and Anti-Trypanosoma cruzi Activity of Diaryldiazepines
Next Article in Special Issue
Potential Amoebicidal Activity of Hydrazone Derivatives: Synthesis, Characterization, Electrochemical Behavior, Theoretical Study and Evaluation of the Biological Activity
Previous Article in Journal
EDTA a Novel Inducer of Pisatin, a Phytoalexin Indicator of the Non-Host Resistance in Peas
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(1), 35-42; doi:10.3390/molecules20010035

Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase

1
Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55 (A. I. Virtasen aukio 1), FI-00014 Helsinki, Finland
2
Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Biocenter 1, Viikinkaari 9), FI-00014 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Christophe Dardonville
Received: 17 November 2014 / Accepted: 15 December 2014 / Published: 23 December 2014
(This article belongs to the Special Issue Antiparasitic Agents)
View Full-Text   |   Download PDF [723 KB, uploaded 23 December 2014]   |  

Abstract

The autoxidation-degradation processes of polyunsaturated fatty acids give rise to toxic products, and the relative toxicity at different stages of the process is of great interest. We report here that when methyl α-linolenate is exposed to sunlight and air, its antimicrobial activity against yeasts and bacteria (as measured by agar diffusion) reaches its maximum during the early oxidative phase when addition of oxygen occurs and the mass increases drastically. Before exposure, the activity is minimal or zero, but it increases rapidly during the first days of the test, simultaneously with the increase of the mass of the material, and begins to decrease while the mass is still increasing and before the mass begins to decrease due to degradation and formation of volatile compounds. Thus, the products formed during the degradation phase of the process are far less toxic to the test organisms than the compounds formed at the early stages when addition of oxygen occurs with maximal rate. View Full-Text
Keywords: polyunsaturated fatty acids; fatty acid esters; autoxidation; weighing method; antibacterial activity; antifungal activity; toxicity; α-linolenic acid methyl ester polyunsaturated fatty acids; fatty acid esters; autoxidation; weighing method; antibacterial activity; antifungal activity; toxicity; α-linolenic acid methyl ester
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Matikainen, J.; Lehtinen, M.; Pelttari, E.; Elo, H. Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase. Molecules 2015, 20, 35-42.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top