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Molecules 2015, 20(1), 1-23; doi:10.3390/molecules20010001

Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems

1
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland
2
Chair of Chemistry, Department of Organic Chemistry, Faculty of Materials Science and Design, Kazimierz Pulaski University of Technology and Humanities in Radom, Chrobrego 27, Radom 26-600, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Atsushi Sudo
Received: 15 October 2014 / Accepted: 16 December 2014 / Published: 23 December 2014
(This article belongs to the Special Issue Ring-Opening Polymerization)
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Abstract

Biodegradable or bioresorbable polymers are commonly used in various pharmaceutical fields (e.g., as drug delivery systems, therapeutic systems or macromolecular drug conjugates). Polyesters are an important class of polymers widely utilized in pharmacy due to their biodegradability and biocompatibility features. In recent years, there has been increased interest in enzyme-catalyzed ring-opening polymerization (e-ROP) of cyclic esters as an alternative method of preparation of biodegradable or bioresorbable polymers. Ionic liquids (ILs) have been presented as green solvents in enzymatic ring-opening polymerization. The activity, stability, selectivity of enzymes in ILs and the ability to catalyze polyester synthesis under these conditions are discussed. Overall, the review demonstrates that e-ROP of lactones or lactides could be an effective method for the synthesis of useful biomedical polymers. View Full-Text
Keywords: biomedical polymers; macromolecular conjugates of drugs; enzymatic ring opening polymerization; ionic liquids; biodegradable polyesters; drug delivery systems biomedical polymers; macromolecular conjugates of drugs; enzymatic ring opening polymerization; ionic liquids; biodegradable polyesters; drug delivery systems
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Piotrowska, U.; Sobczak, M. Enzymatic Polymerization of Cyclic Monomers in Ionic Liquids as a Prospective Synthesis Method for Polyesters Used in Drug Delivery Systems. Molecules 2015, 20, 1-23.

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