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Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes
Department of Organic Technology, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague, Czech Republic
Laboratory of Molecular Structure Characterization, Institute of Microbiology, v.v.i., Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-142 20 Prague, Czech Republic
* Author to whom correspondence should be addressed.
Received: 1 May 2013; in revised form: 27 May 2013 / Accepted: 4 June 2013 / Published: 10 June 2013
Abstract: This review is oriented toward the asymmetric transfer hydrogenation (ATH) of imines regarding mostly fundamental, yet important topics from the practical point of view. Development of analytical methods for the monitoring of ATH (i.e., kinetics and stereoselectivity) belongs to those topics, as well as studies on the influence of reaction conditions and structural variations on the reaction performance. The second part is devoted to the reaction mechanism with the emphasis on imine ATH and catalyst behaviour under acidic conditions. The review also addresses the asymmetric hydrogenation (AH) of ketones and imines using molecular hydrogen and the application of ATH in pharmaceutical projects. The contributions of our group to each area are included.
Keywords: asymmetric hydrogenation; ruthenium; reaction conditions; mechanism; imine
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Václavík, J.; Šot, P.; Vilhanová, B.; Pecháček, J.; Kuzma, M.; Kačer, P. Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes. Molecules 2013, 18, 6804-6828.
Václavík J, Šot P, Vilhanová B, Pecháček J, Kuzma M, Kačer P. Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes. Molecules. 2013; 18(6):6804-6828.
Václavík, Jiří; Šot, Petr; Vilhanová, Beáta; Pecháček, Jan; Kuzma, Marek; Kačer, Petr. 2013. "Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes." Molecules 18, no. 6: 6804-6828.