Special Issue "Asymmetric Catalysis"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 April 2013)
Prof. Dr. Takashi Ohshima
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan
Interests: Lewis acid catalysis; Lewis base catalysit; transition metal catalysis; organocatalysis; enzymatic reaction; multifunctional catalysis; green chemistry
In biological systems, the two enantiomers, in many cases, have a different response. Thus, most of the new drugs reaching the market today are single enantiomers, rather than the racemic mixtures. In addition, nonracemic molecules also contribute to the creation of advanced materials. The synthesis of chiral organic compounds in a highly enantioselective manner is therefore of great importance. In the earliest stages of development, the creation of the chiral center is made possible thanks to chiral substrate, auxiliary, or stoichiometric amounts of chiral reagents. Since the discovery of homogeneous catalytic asymmetric hydrogenation reactions, a variety of highly efficient catalytic asymmetric reactions have been developed so far and research in asymmetric catalysis achieved prominence in both academic and industrial laboratories. Although some of asymmetric catalyses have reached a high level of selectivity and efficiency, interest in further improvements continues to grow period. This special issue of Molecules will highlight all areas of current and future interest, reflecting the tremendous expansion in the scope of the asymmetric catalysis.
I strongly encourage authors to submit their work to this special issue of Molecules.
Prof. Dr. Takashi Ohshima
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
Article: Enantioselective Synthesis of 2,2-Disubstituted Terminal Epoxides via Catalytic Asymmetric Corey-Chaykovsky Epoxidation of Ketones
Molecules 2012, 17(2), 1617-1634; doi:10.3390/molecules17021617
Received: 16 December 2011; in revised form: 23 January 2012 / Accepted: 31 January 2012 / Published: 7 February 2012| Download PDF Full-text (396 KB)
Molecules 2012, 17(5), 5626-5650; doi:10.3390/molecules17055626
Received: 23 March 2012; in revised form: 19 April 2012 / Accepted: 23 April 2012 / Published: 11 May 2012| Download PDF Full-text (638 KB)
Communication: Chiral Bis(Imidazolidine)Pyridine-Cu Complex-Catalyzed Enantioselective [3+2]-Cycloaddition of Azomethine Imines with Propiolates
Molecules 2012, 17(5), 6170-6178; doi:10.3390/molecules17056170
Received: 27 April 2012; in revised form: 18 May 2012 / Accepted: 21 May 2012 / Published: 24 May 2012| Download PDF Full-text (284 KB)
Molecules 2012, 17(6), 6901-6915; doi:10.3390/molecules17066901
Received: 17 April 2012; in revised form: 2 June 2012 / Accepted: 4 June 2012 / Published: 6 June 2012| Download PDF Full-text (342 KB)
Article: Cooperative Al(Salen)-Pyridinium Catalysts for the Asymmetric Synthesis of trans-Configured β-Lactones by [2+2]-Cyclocondensation of Acylbromides and Aldehydes: Investigation of Pyridinium Substituent Effects
Molecules 2012, 17(6), 7121-7150; doi:10.3390/molecules17067121
Received: 26 April 2012; in revised form: 23 May 2012 / Accepted: 4 June 2012 / Published: 12 June 2012| Download PDF Full-text (544 KB)
Article: A New Method for Production of Chiral 2-Aryl-2-fluoropropanoic Acids Using an Effective Kinetic Resolution of Racemic 2-Aryl-2-fluoropropanoic Acids
Molecules 2012, 17(6), 7356-7378; doi:10.3390/molecules17067356
Received: 2 May 2012; in revised form: 4 June 2012 / Accepted: 8 June 2012 / Published: 14 June 2012| Download PDF Full-text (606 KB) | Supplementary Files
Communication: Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst
Molecules 2012, 17(6), 7523-7532; doi:10.3390/molecules17067523
Received: 2 May 2012; in revised form: 6 June 2012 / Accepted: 14 June 2012 / Published: 18 June 2012| Download PDF Full-text (234 KB)
Article: Synthesis of Main-Chain Chiral Quaternary Ammonium Polymers for Asymmetric Catalysis Using Quaternization Polymerization
Molecules 2012, 17(6), 7569-7583; doi:10.3390/molecules17067569
Received: 27 April 2012; in revised form: 4 June 2012 / Accepted: 13 June 2012 / Published: 19 June 2012| Download PDF Full-text (365 KB)
Article: Application Scope and Limitations of TADDOL-Derived Chiral Ammonium Salt Phase-Transfer Catalysts
Molecules 2013, 18(4), 4357-4372; doi:10.3390/molecules18044357
Received: 25 March 2013; in revised form: 8 April 2013 / Accepted: 11 April 2013 / Published: 12 April 2013| Download PDF Full-text (448 KB) | Supplementary Files
Review: Asymmetric Palladium-Catalysed Intramolecular Wacker-Type Cyclisations of Unsaturated Alcohols and Amino Alcohols
Molecules 2013, 18(6), 6173-6192; doi:10.3390/molecules18066173
Received: 28 April 2013; in revised form: 20 May 2013 / Accepted: 20 May 2013 / Published: 24 May 2013| Download PDF Full-text (320 KB)
Review: Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes
Molecules 2013, 18(6), 6804-6828; doi:10.3390/molecules18066804
Received: 1 May 2013; in revised form: 27 May 2013 / Accepted: 4 June 2013 / Published: 10 June 2013| Download PDF Full-text (495 KB)
Article: Mirror-Symmetry-Breaking in Poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-biphenyl] (PF8P2) is Susceptible to Terpene Chirality, Achiral Solvents, and Mechanical Stirring
Molecules 2013, 18(6), 7035-7057; doi:10.3390/molecules18067035
Received: 13 May 2013; in revised form: 3 June 2013 / Accepted: 3 June 2013 / Published: 17 June 2013| Download PDF Full-text (2464 KB)
Article: Enantio- and Periselective Nitroalkene Diels-Alder Reactions Catalyzed by Helical-Chiral Hydrogen Bond Donor Catalysts
Molecules 2013, 18(8), 9982-9998; doi:10.3390/molecules18089982
Received: 15 July 2013; in revised form: 13 August 2013 / Accepted: 14 August 2013 / Published: 19 August 2013| Download PDF Full-text (623 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Catalytic Asymmetric Reactions Using Chiral Imidazoline- or Imidazolidine-metal Complexes.
Author: Takayoshi Arai
Affiliation: Department of Chemistry, Graduate School of Science, Chiba University Inage, Chiba 263-8522, Japan; E-Mail: firstname.lastname@example.org
Abstract: We have succeeded to develop a series of chiral imidzoline- or imidazolidine- consisting ligands for metal-catalyzed reactions. For examples, imidazoline-aminophenol-Cu complex can catalyze the asymmetric Henry reaction and Friedel-Crafts reaction. The newly developed chiral pyridine bis(imidazolidine)-Cu complex becomes quite efficient catalyst for the endo-selective [3+2]-cyclization of iminoesters and nitroalkenes. The resent advances of the metal-catalyzed reactions will be presented.
Type of Paper: Article
Title: Chiral Aminophosphine-Catalyzed Asymmetric Double-Michael Reaction for The Synthesis of Enantioenriched Indolines
Authors: San N. Khong and Ohyun Kwon
Affiliations: Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095-1569, USA; E-Mail: email@example.com
Abstract: The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of a multitude of nitrogen-containing heterocycles. Since the heterocycles thus obtained contain at least one stereogenic center, the double-Michael reaction can be even more useful if an asymmetric variant of the reaction can be developed. Since aminophosphines can also facilitate the double-Michael reaction and chiral amines are more readily available in nature and through synthesis, several new chiral aminophosphines were prepared. When employed in the asymmetric double-Michael reaction of ortho-tosylamidophenyl malonate to activated acetylenes, the chiral aminophosphines produced excellent yields of indolines with moderate asymmetric induction.
Type of Paper: Article
Title: Kinetic Resolution of Racemic Secondary Propargylic Alcohols with Carboxylic Acids via the Asymmetric Esterification: An Application Toward the Total Synthesis of (–)-Tetrahydrolipstatin
Authors: Kenya Nakata and Isamu Shiina *
Affiliation: Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Japan; E-Mail: firstname.lastname@example.org
Abstract: An efficient kinetic resolution of racemic secondary propargylic alcohols with achiral carboxylic acids using pivalic anhydride in the presence of (R)-benzotetramisole ((R)-BTM) was achieved. Several useful synthetic intermediates of natural products were successfully produced by this new effective protocol.
Type of Paper: Article
Title: Synthesis of Main-Chain Chiral Quaternary Ammoniumpolymers for Asymmetric Catalysis
Authors: Naoki Haraguchi, Parbhej Ahmed, Parvez Md. Masud and Shinichi Itsuno
Affiliation: Department of Environmental & Life Sciences, ToyohashiUniversity of Technology, Japan; E-Mail: email@example.com
Abstract: Cinchona alkaloid dimers were easily prepared by variousmethods. Quinuclidine nitrogen of cinchona alkaloid can be easilyquartanarized by halide. When dihalide was allowed to react with thecinchona alkaloid dimer, quaternarization polymerization occurs to givethe novel type of the chiral polymer. The catalytic activity of thepolymeric chiral organocatalyst was investigated.
Last update: 22 October 2012