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Molecules 2013, 18(6), 6573-6583; doi:10.3390/molecules18066573
Article

New Lignans from the Leaves and Stems of Kadsura philippinensis

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6
 and
1,*
1 School of Pharmacy, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Rd., Taipei 100, Taiwan 2 Department of Life Sciences, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan 3 Graduate Institute of Natural Products, School of Pharmacy, Kaohsiung Medical University, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan 4 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 5 Department of Chemistry, National Sun Yat-sen University, 70, Lien-hai Road, Kaohsiung 804, Taiwan 6 Graduate Institute of Ecology and Evolutionary Biology, China Medical University, Taichung 40402, Taiwan
* Author to whom correspondence should be addressed.
Received: 13 May 2013 / Revised: 29 May 2013 / Accepted: 30 May 2013 / Published: 4 June 2013
(This article belongs to the Section Natural Products)
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Abstract

Three novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 15 were determined by spectroscopic analyses, especially 2D NMR techniques. The structure of compound 5 was further confirmed by X-ray crystallographic analysis. Compounds 1 and 2 have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxoethylidene]}-pentano(2,3-dihydrobenzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton.
Keywords: Kadsura philippinensis; taiwankadsurins; lignans Kadsura philippinensis; taiwankadsurins; lignans
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Lin, Y.-C.; Cheng, Y.-B.; Liaw, C.-C.; Lo, I.-W.; Kuo, Y.-H.; Chiang, M.Y.; Chou, C.-H.; Shen, Y.-C. New Lignans from the Leaves and Stems of Kadsura philippinensis. Molecules 2013, 18, 6573-6583.

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