Next Article in Journal
Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization
Previous Article in Journal
One-Step Biofunctionalization of Quantum Dots with Chitosan and N-palmitoyl Chitosan for Potential Biomedical Applications
Molecules 2013, 18(6), 6573-6583; doi:10.3390/molecules18066573

New Lignans from the Leaves and Stems of Kadsura philippinensis

1 School of Pharmacy, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Rd., Taipei 100, Taiwan 2 Department of Life Sciences, National Cheng Kung University, No. 1 University Road, Tainan 701, Taiwan 3 Graduate Institute of Natural Products, School of Pharmacy, Kaohsiung Medical University, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan 4 National Research Institute of Chinese Medicine, Taipei 112, Taiwan 5 Department of Chemistry, National Sun Yat-sen University, 70, Lien-hai Road, Kaohsiung 804, Taiwan 6 Graduate Institute of Ecology and Evolutionary Biology, China Medical University, Taichung 40402, Taiwan
* Author to whom correspondence should be addressed.
Received: 13 May 2013 / Revised: 29 May 2013 / Accepted: 30 May 2013 / Published: 4 June 2013
(This article belongs to the Section Metabolites)
Download PDF [429 KB, uploaded 18 June 2014]


Three novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 15 were determined by spectroscopic analyses, especially 2D NMR techniques. The structure of compound 5 was further confirmed by X-ray crystallographic analysis. Compounds 1 and 2 have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxoethylidene]}-pentano(2,3-dihydrobenzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton.
Keywords: Kadsura philippinensis; taiwankadsurins; lignans Kadsura philippinensis; taiwankadsurins; lignans
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Lin, Y.-C.; Cheng, Y.-B.; Liaw, C.-C.; Lo, I.-W.; Kuo, Y.-H.; Chiang, M.Y.; Chou, C.-H.; Shen, Y.-C. New Lignans from the Leaves and Stems of Kadsura philippinensis. Molecules 2013, 18, 6573-6583.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert